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10.1111/febs.13035 http://scihub22266oqcxt.onion/10.1111/febs.13035 C4364409!4364409 !25205393     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25205393 &cmd=llinks): Failed to open stream: HTTP request failed! 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Signal transducer and activator of transcription 3 and the phosphatidylinositol 3-kinase regulatory subunits p55? and p50? regulate autophagy in vivo |pdf=|usr=}}{{25205393 }} gab.com Text Signal transducer and activator of transcription 3 and the phosphatidylinositol 3-kinase regulatory subunits p55 and p50 regulate autophagy in vivo JO: FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=25205393 #FOAvip Mammary gland involution involves a process that includes one of the most dramatic examples of cell death in an adult mammalian organism. We have previously shown that signal transducer and activator of transcription 3 (Stat3) regulates a lysosomal pathway of cell death in the first 48 h of involution and induces lysosome leakiness in mammary epithelial cells. Interestingly, Stat3 is associated also with the striking induction of autophagy that occurs concomitantly with cell death, presumably as a transient survival mechanism. The phosphatidylinositol 3-kinase regulatory subunits p55? and p50? are dramatically and specifically upregulated at the transcriptional level by Stat3 at the onset of involution. We show here that ablation of either Stat3 or p55?/p50? in vivo affects autophagy during involution. We used two different cell culture models (normal mammary epithelial cells and mouse embryonic fibroblasts) to further investigate the role of p55?/p50? in autophagy regulation. Our results demonstrate a direct role for p55?/p50? as inhibitors of autophagy mediated by p85?. Thus, Stat3 and its downstream targets p55?/p50? are key regulators of the balance between autophagy and cell death in vivo. Twit Text FOAVip Signal transducer and activator of transcription 3 and the phosphatidylinositol 3-kinase regulatory subunits p55 and p50 regulate autophagy in vivo ????FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=25205393 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25205393 #FOAvip English Wikipedia <ref>{{Cite pmid|25205393 }}</ref> Signal transducer and activator of transcription 3 and the phosphatidylinositol 3-kinase regulatory subunits p55? and p50? regulate autophagy in vivo #MMPMID25205393 Pensa S ; Lloyd-Lewis B ; Sargeant TJ ; Resemann HK ; Kahn CR ; Watson CJ FEBS J 2014[Oct]; 281 (20 ): 4557-67 PMID25205393 show ga Mammary gland involution involves a process that includes one of the most dramatic examples of cell death in an adult mammalian organism. We have previously shown that signal transducer and activator of transcription 3 (Stat3) regulates a lysosomal pathway of cell death in the first 48 h of involution and induces lysosome leakiness in mammary epithelial cells. Interestingly, Stat3 is associated also with the striking induction of autophagy that occurs concomitantly with cell death, presumably as a transient survival mechanism. The phosphatidylinositol 3-kinase regulatory subunits p55? and p50? are dramatically and specifically upregulated at the transcriptional level by Stat3 at the onset of involution. We show here that ablation of either Stat3 or p55?/p50? in vivo affects autophagy during involution. We used two different cell culture models (normal mammary epithelial cells and mouse embryonic fibroblasts) to further investigate the role of p55?/p50? in autophagy regulation. Our results demonstrate a direct role for p55?/p50? as inhibitors of autophagy mediated by p85?. Thus, Stat3 and its downstream targets p55?/p50? are key regulators of the balance between autophagy and cell death in vivo. |*Autophagy [MESH] |Animals [MESH] |Blotting, Western [MESH] |Cells, Cultured [MESH] |Class Ia Phosphatidylinositol 3-Kinase/*physiology [MESH] |Embryo, Mammalian/metabolism/*pathology [MESH] |Female [MESH] |Fibroblasts/metabolism/pathology [MESH] |Immunoenzyme Techniques [MESH] |Mammary Glands, Animal/metabolism/*pathology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |RNA, Messenger/genetics [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH]Signal transducer and activator of transcription 3 and the phosphatidy(epmc).pdf DeepDyve Pubget Overpricing