Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1073/pnas.1414156112 http://scihub22266oqcxt.onion/10.1073/pnas.1414156112 C4364239!4364239!25713388     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (10): 3068-73 Nephropedia Template TP {{tp|p=25713388|t=2015. Detecting cancers through tumor-activatable minicircles that lead to a detectable blood biomarker |pdf=|usr=}}{{25713388}} gab.com Text Detecting cancers through tumor-activatable minicircles that lead to a detectable blood biomarker JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25713388 #FOAvip Blood-based cancer diagnosis is highly attractive, but current strategies suffer because they rely on the detection of endogenous molecules that often are secreted into the circulation by both malignant and nonmalignant cells. One solution to this problem is to avoid nonmalignant tissue expression by artificially engineering tumor cells to express a unique reporter not normally expressed by any tissue. This study shows that systemic administration of nonviral safe vectors we call ?tumor-activatable minicircles? allows one to distinguish tumor-bearing from tumor-free subjects reliably and to assess tumor burden simply by measuring blood levels of such a reporter. Our system represents an alternative paradigm for improved cancer detection and could enable more timely interventions to combat this devastating disease. Twit Text FOAVip Detecting cancers through tumor-activatable minicircles that lead to a detectable blood biomarker ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25713388 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25713388 #FOAvip English Wikipedia <ref>{{Cite pmid|25713388}}</ref> Detecting cancers through tumor-activatable minicircles that lead to a detectable blood biomarker #MMPMID25713388 Ronald JA; Chuang HY; Dragulescu-Andrasi A; Hori SS; Gambhir SS Proc Natl Acad Sci U S A 2015[Mar]; 112 (10): 3068-73 PMID25713388show ga Blood-based cancer diagnosis is highly attractive, but current strategies suffer because they rely on the detection of endogenous molecules that often are secreted into the circulation by both malignant and nonmalignant cells. One solution to this problem is to avoid nonmalignant tissue expression by artificially engineering tumor cells to express a unique reporter not normally expressed by any tissue. This study shows that systemic administration of nonviral safe vectors we call ?tumor-activatable minicircles? allows one to distinguish tumor-bearing from tumor-free subjects reliably and to assess tumor burden simply by measuring blood levels of such a reporter. Our system represents an alternative paradigm for improved cancer detection and could enable more timely interventions to combat this devastating disease. äDetecting cancers through tumor-activatable minicircles that lead to a(epmc).pdf DeepDyve Pubget Overpricing