Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1073/pnas.1424796112 http://scihub22266oqcxt.onion/10.1073/pnas.1424796112 C4364210!4364210!25713364     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (10): 3044-9 Nephropedia Template TP {{tp|p=25713364|t=2015. Tetramers reveal IL-17?secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease |pdf=|usr=}}{{25713364}} gab.com Text Tetramers reveal IL-17 secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25713364 #FOAvip Patients with the autoimmune disease systemic lupus erythematosus (SLE) develop pathogenic antibodies against their own ?self?-antigens. The development of such autoantibodies is thought in part to require help from CD4+ T cells that also recognize the same self-antigens and direct autoantibody production. In this study, antigen-specific CD4+ T cells in lupus are identified and tracked for the first time using tetramers containing peptides from the spliceosomal protein U1-70. The proportion of circulating, tetramer-positive CD4+ cells correlates with the presence of U1-70?specific autoantibodies, and antigen-specific T cells are directly implicated in disease activity by their production of the proinflammatory cytokine IL-17. The role of these cells in disease pathology makes them candidate targets for therapeutic intervention. Twit Text FOAVip Tetramers reveal IL-17 secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25713364 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25713364 #FOAvip English Wikipedia <ref>{{Cite pmid|25713364}}</ref> Tetramers reveal IL-17?secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease #MMPMID25713364 Kattah NH; Newell EW; Jarrell JA; Chu AD; Xie J; Kattah MG; Goldberger O; Ye J; Chakravarty EF; Davis MM; Utz PJ Proc Natl Acad Sci U S A 2015[Mar]; 112 (10): 3044-9 PMID25713364show ga Patients with the autoimmune disease systemic lupus erythematosus (SLE) develop pathogenic antibodies against their own ?self?-antigens. The development of such autoantibodies is thought in part to require help from CD4+ T cells that also recognize the same self-antigens and direct autoantibody production. In this study, antigen-specific CD4+ T cells in lupus are identified and tracked for the first time using tetramers containing peptides from the spliceosomal protein U1-70. The proportion of circulating, tetramer-positive CD4+ cells correlates with the presence of U1-70?specific autoantibodies, and antigen-specific T cells are directly implicated in disease activity by their production of the proinflammatory cytokine IL-17. The role of these cells in disease pathology makes them candidate targets for therapeutic intervention. äTetramers reveal IL-17?secreting CD4+ T cells that are specific for U1(epmc).pdf DeepDyve Pubget Overpricing