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10.1016/j.molcel.2014.08.022 http://scihub22266oqcxt.onion/10.1016/j.molcel.2014.08.022 C4363072!4363072 !25263594     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25263594 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell 2014 ; 56 (2 ): 298-310 Nephropedia Template TP {{tp|p=25263594 |t=2014. BS69/ZMYND11 reads and connects histone H3 3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing |pdf=|usr=}}{{25263594 }} gab.com Text BS69/ZMYND11 reads and connects histone H3 3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25263594 #FOAvip BS69 (also called ZMYND11) contains tandemly arranged PHD, BROMO, and PWWP domains, which are chromatin recognition modalities. Here, we show that BS69 selectively recognizes histone variant H3.3 lysine 36 trimethylation (H3.3K36me3) via its chromatin-binding domains. We further identify BS69 association with RNA splicing regulators, including the U5 snRNP components of the spliceosome, such as EFTUD2. Remarkably, RNA sequencing shows that BS69 mainly regulates intron retention (IR), which is the least understood RNA alternative splicing event in mammalian cells. Biochemical and genetic experiments demonstrate that BS69 promotes IR by antagonizing EFTUD2 through physical interactions. We further show that regulation of IR by BS69 also depends on its binding to H3K36me3-decorated chromatin. Taken together, our study identifies an H3.3K36me3-specific reader and a regulator of IR and reveals that BS69 connects histone H3.3K36me3 to regulated RNA splicing, providing significant, important insights into chromatin regulation of pre-mRNA processing. Twit Text FOAVip BS69/ZMYND11 reads and connects histone H3 3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25263594 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25263594 #FOAvip English Wikipedia <ref>{{Cite pmid|25263594 }}</ref> BS69/ZMYND11 reads and connects histone H3 3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing #MMPMID25263594 Guo R ; Zheng L ; Park JW ; Lv R ; Chen H ; Jiao F ; Xu W ; Mu S ; Wen H ; Qiu J ; Wang Z ; Yang P ; Wu F ; Hui J ; Fu X ; Shi X ; Shi YG ; Xing Y ; Lan F ; Shi Y Mol Cell 2014[Oct]; 56 (2 ): 298-310 PMID25263594 show ga BS69 (also called ZMYND11) contains tandemly arranged PHD, BROMO, and PWWP domains, which are chromatin recognition modalities. Here, we show that BS69 selectively recognizes histone variant H3.3 lysine 36 trimethylation (H3.3K36me3) via its chromatin-binding domains. We further identify BS69 association with RNA splicing regulators, including the U5 snRNP components of the spliceosome, such as EFTUD2. Remarkably, RNA sequencing shows that BS69 mainly regulates intron retention (IR), which is the least understood RNA alternative splicing event in mammalian cells. Biochemical and genetic experiments demonstrate that BS69 promotes IR by antagonizing EFTUD2 through physical interactions. We further show that regulation of IR by BS69 also depends on its binding to H3K36me3-decorated chromatin. Taken together, our study identifies an H3.3K36me3-specific reader and a regulator of IR and reveals that BS69 connects histone H3.3K36me3 to regulated RNA splicing, providing significant, important insights into chromatin regulation of pre-mRNA processing. |*Alternative Splicing [MESH] |Base Sequence [MESH] |Carrier Proteins/genetics/*metabolism [MESH] |Cell Cycle Proteins [MESH] |Cell Line, Tumor [MESH] |Chromatin/genetics/*metabolism [MESH] |Co-Repressor Proteins [MESH] |DNA Methylation/genetics [MESH] |DNA-Binding Proteins [MESH] |HeLa Cells [MESH] |Histone-Lysine N-Methyltransferase/genetics/metabolism [MESH] |Histones/genetics/*metabolism [MESH] |Humans [MESH] |Introns/genetics [MESH] |Lysine/genetics/metabolism [MESH] |Peptide Elongation Factors/antagonists & inhibitors/genetics/metabolism [MESH] |Protein Binding [MESH] |Protein Structure, Tertiary [MESH] |RNA Interference [MESH] |RNA Precursors/*genetics [MESH] |RNA Processing, Post-Transcriptional/genetics [MESH] |RNA, Messenger/*genetics [MESH] |RNA, Small Interfering [MESH] |Ribonucleoprotein, U5 Small Nuclear/antagonists & inhibitors/genetics/metabolism [MESH] |Sequence Analysis, RNA [MESH]BS69/ZMYND11 reads and connects histone H3 3 lysine 36 trimethylation-(epmc).pdf DeepDyve Pubget Overpricing