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10.1083/jcb.201407016 http://scihub22266oqcxt.onion/10.1083/jcb.201407016 C4362453!4362453 !25778919     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25778919 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2015 ; 208 (6 ): 713-27 Nephropedia Template TP {{tp|p=25778919 |t=2015. Aurora B prevents chromosome arm separation defects by promoting telomere dispersion and disjunction |pdf=|usr=}}{{25778919 }} gab.com Text Aurora B prevents chromosome arm separation defects by promoting telomere dispersion and disjunction JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25778919 #FOAvip The segregation of centromeres and telomeres at mitosis is coordinated at multiple levels to prevent the formation of aneuploid cells, a phenotype frequently observed in cancer. Mitotic instability arises from chromosome segregation defects, giving rise to chromatin bridges at anaphase. Most of these defects are corrected before anaphase onset by a mechanism involving Aurora B kinase, a key regulator of mitosis in a wide range of organisms. Here, we describe a new role for Aurora B in telomere dispersion and disjunction during fission yeast mitosis. Telomere dispersion initiates in metaphase, whereas disjunction takes place in anaphase. Dispersion is promoted by the dissociation of Swi6/HP1 and cohesin Rad21 from telomeres, whereas disjunction occurs at anaphase after the phosphorylation of condensin subunit Cnd2. Strikingly, we demonstrate that deletion of Ccq1, a telomeric shelterin component, rescued cell death after Aurora inhibition by promoting the loading of condensin on chromosome arms. Our findings reveal an essential role for telomeres in chromosome arm segregation. Twit Text FOAVip Aurora B prevents chromosome arm separation defects by promoting telomere dispersion and disjunction ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25778919 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25778919 #FOAvip English Wikipedia <ref>{{Cite pmid|25778919 }}</ref> Aurora B prevents chromosome arm separation defects by promoting telomere dispersion and disjunction #MMPMID25778919 Reyes C ; Serrurier C ; Gauthier T ; Gachet Y ; Tournier S J Cell Biol 2015[Mar]; 208 (6 ): 713-27 PMID25778919 show ga The segregation of centromeres and telomeres at mitosis is coordinated at multiple levels to prevent the formation of aneuploid cells, a phenotype frequently observed in cancer. Mitotic instability arises from chromosome segregation defects, giving rise to chromatin bridges at anaphase. Most of these defects are corrected before anaphase onset by a mechanism involving Aurora B kinase, a key regulator of mitosis in a wide range of organisms. Here, we describe a new role for Aurora B in telomere dispersion and disjunction during fission yeast mitosis. Telomere dispersion initiates in metaphase, whereas disjunction takes place in anaphase. Dispersion is promoted by the dissociation of Swi6/HP1 and cohesin Rad21 from telomeres, whereas disjunction occurs at anaphase after the phosphorylation of condensin subunit Cnd2. Strikingly, we demonstrate that deletion of Ccq1, a telomeric shelterin component, rescued cell death after Aurora inhibition by promoting the loading of condensin on chromosome arms. Our findings reveal an essential role for telomeres in chromosome arm segregation. |Adenosine Triphosphatases/metabolism [MESH] |Aurora Kinases/*physiology [MESH] |Cell Cycle Proteins/metabolism [MESH] |Chromatin/metabolism [MESH] |Chromosomal Proteins, Non-Histone/metabolism [MESH] |Chromosomes, Fungal/*physiology [MESH] |DNA-Binding Proteins/metabolism [MESH] |Mitosis [MESH] |Multiprotein Complexes/metabolism [MESH] |Nondisjunction, Genetic [MESH] |Nuclear Proteins/metabolism [MESH] |Phosphoproteins/metabolism [MESH] |Phosphorylation [MESH] |Protein Processing, Post-Translational [MESH] |Schizosaccharomyces pombe Proteins/metabolism/*physiology [MESH] |Schizosaccharomyces/cytology/*enzymology/genetics [MESH] |Shelterin Complex [MESH] |Spindle Apparatus/metabolism [MESH] |Telomere-Binding Proteins/metabolism [MESH]Aurora B prevents chromosome arm separation defects by promoting telom(epmc).pdf DeepDyve Pubget Overpricing