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10.1172/JCI76452 http://scihub22266oqcxt.onion/10.1172/JCI76452 C4362247!4362247!25689248     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2015 ; 125 (3): 1269-85 Nephropedia Template TP {{tp|p=25689248|t=2015. WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited |pdf=|usr=}}{{25689248}} gab.com Text WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25689248 #FOAvip Cholangiocarcinoma (CC) is typically diagnosed at an advanced stage and is refractory to surgical intervention and chemotherapy. Despite a global increase in the incidence of CC, little progress has been made toward the development of treatments for this cancer. Here we utilized human tissue; CC cell xenografts; a p53-deficient transgenic mouse model; and a non-transgenic, chemically induced rat model of CC that accurately reflects both the inflammatory and regenerative background associated with human CC pathology. Using these systems, we determined that the WNT pathway is highly activated in CCs and that inflammatory macrophages are required to establish this WNT-high state in vivo. Moreover, depletion of macrophages or inhibition of WNT signaling with one of two small molecule WNT inhibitors in mouse and rat CC models markedly reduced CC proliferation and increased apoptosis, resulting in tumor regression. Together, these results demonstrate that enhanced WNT signaling is a characteristic of CC and suggest that targeting WNT signaling pathways has potential as a therapeutic strategy for CC. Twit Text FOAVip WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25689248 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25689248 #FOAvip English Wikipedia <ref>{{Cite pmid|25689248}}</ref> WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited #MMPMID25689248 Boulter L; Guest RV; Kendall TJ; Wilson DH; Wojtacha D; Robson AJ; Ridgway RA; Samuel K; Van Rooijen N; Barry ST; Wigmore SJ; Sansom OJ; Forbes SJ J Clin Invest 2015[Mar]; 125 (3): 1269-85 PMID25689248show ga Cholangiocarcinoma (CC) is typically diagnosed at an advanced stage and is refractory to surgical intervention and chemotherapy. Despite a global increase in the incidence of CC, little progress has been made toward the development of treatments for this cancer. Here we utilized human tissue; CC cell xenografts; a p53-deficient transgenic mouse model; and a non-transgenic, chemically induced rat model of CC that accurately reflects both the inflammatory and regenerative background associated with human CC pathology. Using these systems, we determined that the WNT pathway is highly activated in CCs and that inflammatory macrophages are required to establish this WNT-high state in vivo. Moreover, depletion of macrophages or inhibition of WNT signaling with one of two small molecule WNT inhibitors in mouse and rat CC models markedly reduced CC proliferation and increased apoptosis, resulting in tumor regression. Together, these results demonstrate that enhanced WNT signaling is a characteristic of CC and suggest that targeting WNT signaling pathways has potential as a therapeutic strategy for CC. äWNT signaling drives cholangiocarcinoma growth and can be pharmacologi(epmc).pdf DeepDyve Pubget Overpricing