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10.1172/JCI77278 http://scihub22266oqcxt.onion/10.1172/JCI77278 C4362242!4362242!25621495     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2015 ; 125 (3): 1019-32 Nephropedia Template TP {{tp|p=25621495|t=2015. CRK proteins selectively regulate T cell migration into inflamed tissues |pdf=|usr=}}{{25621495}} gab.com Text CRK proteins selectively regulate T cell migration into inflamed tissues JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25621495 #FOAvip Effector T cell migration into inflamed sites greatly exacerbates tissue destruction and disease severity in inflammatory diseases, including graft-versus-host disease (GVHD). T cell migration into such sites depends heavily on regulated adhesion and migration, but the signaling pathways that coordinate these functions downstream of chemokine receptors are largely unknown. Using conditional knockout mice, we found that T cells lacking the adaptor proteins CRK and CRK-like (CRKL) exhibit reduced integrin-dependent adhesion, chemotaxis, and diapedesis. Moreover, these two closely related proteins exhibited substantial functional redundancy, as ectopic expression of either protein rescued defects in T cells lacking both CRK and CRKL. We determined that CRK proteins coordinate with the RAP guanine nucleotide exchange factor C3G and the adhesion docking molecule CASL to activate the integrin regulatory GTPase RAP1. CRK proteins were required for effector T cell trafficking into sites of inflammation, but not for migration to lymphoid organs. In a murine bone marrow transplantation model, the differential migration of CRK/CRKL-deficient T cells resulted in efficient graft-versus-leukemia responses with minimal GVHD. Together, the results from our studies show that CRK family proteins selectively regulate T cell adhesion and migration at effector sites and suggest that these proteins have potential as therapeutic targets for preventing GVHD. Twit Text FOAVip CRK proteins selectively regulate T cell migration into inflamed tissues ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25621495 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25621495 #FOAvip English Wikipedia <ref>{{Cite pmid|25621495}}</ref> CRK proteins selectively regulate T cell migration into inflamed tissues #MMPMID25621495 Huang Y; Clarke F; Karimi M; Roy NH; Williamson EK; Okumura M; Mochizuki K; Chen EJ; Park TJ; Debes GF; Zhang Y; Curran T; Kambayashi T; Burkhardt JK J Clin Invest 2015[Mar]; 125 (3): 1019-32 PMID25621495show ga Effector T cell migration into inflamed sites greatly exacerbates tissue destruction and disease severity in inflammatory diseases, including graft-versus-host disease (GVHD). T cell migration into such sites depends heavily on regulated adhesion and migration, but the signaling pathways that coordinate these functions downstream of chemokine receptors are largely unknown. Using conditional knockout mice, we found that T cells lacking the adaptor proteins CRK and CRK-like (CRKL) exhibit reduced integrin-dependent adhesion, chemotaxis, and diapedesis. Moreover, these two closely related proteins exhibited substantial functional redundancy, as ectopic expression of either protein rescued defects in T cells lacking both CRK and CRKL. We determined that CRK proteins coordinate with the RAP guanine nucleotide exchange factor C3G and the adhesion docking molecule CASL to activate the integrin regulatory GTPase RAP1. CRK proteins were required for effector T cell trafficking into sites of inflammation, but not for migration to lymphoid organs. In a murine bone marrow transplantation model, the differential migration of CRK/CRKL-deficient T cells resulted in efficient graft-versus-leukemia responses with minimal GVHD. Together, the results from our studies show that CRK family proteins selectively regulate T cell adhesion and migration at effector sites and suggest that these proteins have potential as therapeutic targets for preventing GVHD. äCRK proteins selectively regulate T cell migration into inflamed tissu(epmc).pdf DeepDyve Pubget Overpricing