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10.1172/JCI76344 http://scihub22266oqcxt.onion/10.1172/JCI76344 C4362239!4362239!25642769     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2015 ; 125 (3): 1098-110 Nephropedia Template TP {{tp|p=25642769|t=2015. Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation |pdf=|usr=}}{{25642769}} gab.com Text Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25642769 #FOAvip The intracellular protein HMGB1 is released from cells and acts as a damage-associated molecular pattern molecule during many diseases, including inflammatory bowel disease (IBD); however, the intracellular function of HMGB1 during inflammation is poorly understood. Here, we demonstrated that cytosolic HMGB1 regulates apoptosis by protecting the autophagy proteins beclin 1 and ATG5 from calpain-mediated cleavage during inflammation. Colitis in mice with an intestinal epithelial cell?specific Hmgb1 deletion and patients with IBD were both characterized by increased calpain activation, beclin 1 and ATG5 cleavage, and intestinal epithelial cell (IEC) death compared with controls. In vitro cleavage assays and studies of enteroids verified that HMGB1 protects beclin 1 and ATG5 from calpain-mediated cleavage events that generate proapoptotic protein fragments. Together, our results indicate that HMGB1 is essential for mitigating the extent and severity of inflammation-associated cellular injury by controlling the switch between the proautophagic and proapoptotic functions of beclin 1 and ATG5 during inflammation. Moreover, these studies demonstrate that HMGB1 is pivotal for reducing tissue injury in IBD and other complex inflammatory disorders. Twit Text FOAVip Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25642769 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25642769 #FOAvip English Wikipedia <ref>{{Cite pmid|25642769}}</ref> Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation #MMPMID25642769 Zhu X; Messer JS; Wang Y; Lin F; Cham CM; Chang J; Billiar TR; Lotze MT; Boone DL; Chang EB J Clin Invest 2015[Mar]; 125 (3): 1098-110 PMID25642769show ga The intracellular protein HMGB1 is released from cells and acts as a damage-associated molecular pattern molecule during many diseases, including inflammatory bowel disease (IBD); however, the intracellular function of HMGB1 during inflammation is poorly understood. Here, we demonstrated that cytosolic HMGB1 regulates apoptosis by protecting the autophagy proteins beclin 1 and ATG5 from calpain-mediated cleavage during inflammation. Colitis in mice with an intestinal epithelial cell?specific Hmgb1 deletion and patients with IBD were both characterized by increased calpain activation, beclin 1 and ATG5 cleavage, and intestinal epithelial cell (IEC) death compared with controls. In vitro cleavage assays and studies of enteroids verified that HMGB1 protects beclin 1 and ATG5 from calpain-mediated cleavage events that generate proapoptotic protein fragments. Together, our results indicate that HMGB1 is essential for mitigating the extent and severity of inflammation-associated cellular injury by controlling the switch between the proautophagic and proapoptotic functions of beclin 1 and ATG5 during inflammation. Moreover, these studies demonstrate that HMGB1 is pivotal for reducing tissue injury in IBD and other complex inflammatory disorders. äCytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint d(epmc).pdf DeepDyve Pubget Overpricing