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10.1172/JCI74725 http://scihub22266oqcxt.onion/10.1172/JCI74725 C4362236!4362236!25664850     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2015 ; 125 (3): 1147-62 Nephropedia Template TP {{tp|p=25664850|t=2015. Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma |pdf=|usr=}}{{25664850}} gab.com Text Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25664850 #FOAvip Epithelial tumor metastasis is preceded by an accumulation of collagen cross-links that heighten stromal stiffness and stimulate the invasive properties of tumor cells. However, the biochemical nature of collagen cross-links in cancer is still unclear. Here, we postulated that epithelial tumorigenesis is accompanied by changes in the biochemical type of collagen cross-links. Utilizing resected human lung cancer tissues and a p21CIP1/WAF1-deficient, K-rasG12D-expressing murine metastatic lung cancer model, we showed that, relative to normal lung tissues, tumor stroma contains higher levels of hydroxylysine aldehyde?derived collagen cross-links (HLCCs) and lower levels of lysine aldehyde?derived cross-links (LCCs), which are the predominant types of collagen cross-links in skeletal tissues and soft tissues, respectively. Gain- and loss-of-function studies in tumor cells showed that lysyl hydroxylase 2 (LH2), which hydroxylates telopeptidyl lysine residues on collagen, shifted the tumor stroma toward a high-HLCC, low-LCC state, increased tumor stiffness, and enhanced tumor cell invasion and metastasis. Together, our data indicate that LH2 enhances the metastatic properties of tumor cells and functions as a regulatory switch that controls the relative abundance of biochemically distinct types of collagen cross-links in the tumor stroma. Twit Text FOAVip Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25664850 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25664850 #FOAvip English Wikipedia <ref>{{Cite pmid|25664850}}</ref> Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma #MMPMID25664850 Chen Y; Terajima M; Yang Y; Sun L; Ahn YH; Pankova D; Puperi DS; Watanabe T; Kim MP; Blackmon SH; Rodriguez J; Liu H; Behrens C; Wistuba II; Minelli R; Scott KL; Sanchez-Adams J; Guilak F; Pati D; Thilaganathan N; Burns AR; Creighton CJ; Martinez ED; Zal T; Grande-Allen KJ; Yamauchi M; Kurie JM J Clin Invest 2015[Mar]; 125 (3): 1147-62 PMID25664850show ga Epithelial tumor metastasis is preceded by an accumulation of collagen cross-links that heighten stromal stiffness and stimulate the invasive properties of tumor cells. However, the biochemical nature of collagen cross-links in cancer is still unclear. Here, we postulated that epithelial tumorigenesis is accompanied by changes in the biochemical type of collagen cross-links. Utilizing resected human lung cancer tissues and a p21CIP1/WAF1-deficient, K-rasG12D-expressing murine metastatic lung cancer model, we showed that, relative to normal lung tissues, tumor stroma contains higher levels of hydroxylysine aldehyde?derived collagen cross-links (HLCCs) and lower levels of lysine aldehyde?derived cross-links (LCCs), which are the predominant types of collagen cross-links in skeletal tissues and soft tissues, respectively. Gain- and loss-of-function studies in tumor cells showed that lysyl hydroxylase 2 (LH2), which hydroxylates telopeptidyl lysine residues on collagen, shifted the tumor stroma toward a high-HLCC, low-LCC state, increased tumor stiffness, and enhanced tumor cell invasion and metastasis. Together, our data indicate that LH2 enhances the metastatic properties of tumor cells and functions as a regulatory switch that controls the relative abundance of biochemically distinct types of collagen cross-links in the tumor stroma. äLysyl hydroxylase 2 induces a collagen cross-link switch in tumor stro(epmc).pdf DeepDyve Pubget Overpricing