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Long-term oral nutrition supplementation improves outcomes in malnourished
patients with chronic kidney disease on hemodialysis
#MMPMID24436491
Sezer S
; Bal Z
; Tutal E
; Uyar ME
; Acar NO
JPEN J Parenter Enteral Nutr
2014[Nov]; 38
(8
): 960-5
PMID24436491
show ga
BACKGROUND: There is no consensus on the type, time of initiation, or duration of
use of enteral nutrition in patients with chronic kidney disease (CKD). This
study aimed to compare the effects of a renal-specific oral nutrition supplement
(RS-ONS) and a standard recommended nutrition regime on biochemical and nutrition
markers in malnourished patients with CKD on hemodialysis. METHODS: Sixty-two
malnourished patients with CKD, divided into experimental (RS-ONS; n = 32; mean
[SD] age, 62.0 [11.3] years; 55.2% female) and control (CON; n = 30; mean [SD]
age, 57.2 [12.3] years; 31% female) groups, were evaluated for anthropometric,
biochemical, and inflammatory parameters. RESULTS: Mean (SD) serum albumin levels
were significantly increased in the RS-ONS group from 3.5 (0.3) g/dL at baseline
to 3.7 (0.2) g/dL at 6 months (P = .028). Significantly fewer patients had serum
albumin levels of <3.5 g/dL after month 6. Dry weight of patients significantly
increased in the RS-ONS but decreased in the CON groups (P < .001 for each).
Percent change from baseline revealed negative results for bioelectrical
impedance analysis (P < .001) in the CON group. Malnutrition inflammation score
at 6 months (P = .006) and erythropoietin (EPO) dose requirements were higher in
the CON group (P = .012). CONCLUSIONS: Our findings indicate that consuming
RS-ONS improves serum albumin and anthropometric measures, as well as reduces EPO
dose, in patients with CKD.
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