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10.1016/j.celrep.2015.01.057 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.01.057 C4361231!4361231!25732817     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2015 ; 10 (8): 1261-8 Nephropedia Template TP {{tp|p=25732817|t=2015. A small molecule screen for enhanced homing of systemically infused cells |pdf=|usr=}}{{25732817}} gab.com Text A small molecule screen for enhanced homing of systemically infused cells JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25732817 #FOAvip Poor homing of systemically infused cells to disease sites may limit the success of exogenous cell-based therapy. In this study, we screened 9,000 signal transduction modulators to identify hits that increase mesenchymal stromal cell (MSC) surface expression of homing ligands that bind to ICAM-1, such as CD11a. Pretreatment of MSCs with Ro-31-8425, an identified hit from this screen, increased MSC firm adhesion to an ICAM-1-coated substrate in-vitro, and enabled targeted delivery of systemically administered MSCs to inflamed sites in-vivo in a CD11a (and other ICAM-1-binding domains)-dependent manner. This resulted in a heightened anti-inflammatory response. This represents a new strategy for engineering cell homing to enhance therapeutic efficacy and validates CD11a/ICAM-1 as potential targets. Altogether, this multi-step screening process may significantly improve clinical outcomes of cell-based therapies. Twit Text FOAVip A small molecule screen for enhanced homing of systemically infused cells ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25732817 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25732817 #FOAvip English Wikipedia <ref>{{Cite pmid|25732817}}</ref> A small molecule screen for enhanced homing of systemically infused cells #MMPMID25732817 Levy O; Mortensen LJ; Boquet G; Tong Z; Perrault C; Benhamou B; Zhang J; Stratton T; Han E; Safaee H; Musabeyezu J; Yang Z; Multon MC; Rothblatt J; Deleuze JF; Lin CP; Karp JM Cell Rep 2015[Mar]; 10 (8): 1261-8 PMID25732817show ga Poor homing of systemically infused cells to disease sites may limit the success of exogenous cell-based therapy. In this study, we screened 9,000 signal transduction modulators to identify hits that increase mesenchymal stromal cell (MSC) surface expression of homing ligands that bind to ICAM-1, such as CD11a. Pretreatment of MSCs with Ro-31-8425, an identified hit from this screen, increased MSC firm adhesion to an ICAM-1-coated substrate in-vitro, and enabled targeted delivery of systemically administered MSCs to inflamed sites in-vivo in a CD11a (and other ICAM-1-binding domains)-dependent manner. This resulted in a heightened anti-inflammatory response. This represents a new strategy for engineering cell homing to enhance therapeutic efficacy and validates CD11a/ICAM-1 as potential targets. Altogether, this multi-step screening process may significantly improve clinical outcomes of cell-based therapies. äA small molecule screen for enhanced homing of systemically infused ce(epmc).pdf DeepDyve Pubget Overpricing