Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.jaut.2014.03.005 http://scihub22266oqcxt.onion/10.1016/j.jaut.2014.03.005 C4361177!4361177!24767831     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Autoimmun 2014 ; 53 (ä): 85-94 Nephropedia Template TP {{tp|p=24767831|t=2014. Long Term Effect of Gut Microbiota Transfer on Diabetes Development |pdf=|usr=}}{{24767831}} gab.com Text Long Term Effect of Gut Microbiota Transfer on Diabetes Development JO: J Autoimmun http://www.kidney.de/pget.php?&tw=1&pmid=24767831 #FOAvip The composition of the gut microbiome represents a very important environmental factor that influences the development of type 1 diabetes (T1D). We have previously shown that MyD88-deficient non-obese diabetic (MyD88?/?NOD) mice, that were protected from T1D development, had a different composition of gut microbiota compared to wild type NOD mice. The aim of our study was to investigate whether this protection could be transferred. We demonstrate that transfer of gut microbiota from diabetes-protected MyD88-deficient NOD mice, reduced insulitis and significantly delayed the onset of diabetes. Gut bacteria from MyD88-deficient mice, administered over a 3-week period, starting at 4 weeks of age, stably altered the family composition of the gut microbiome, with principally Lachnospiraceae and Clostridiaceae increased and Lactobacillaceae decreased. The transferred mice had a higher concentration of IgA and TGF? in the lumen that was accompanied by an increase in CD8+CD103+ and CD8?? T cells in the lamina propria of the large intestine. These data indicate not only that gut bacterial composition can be altered after the neonatal/weaning period, but that the composition of the microbiome affects the mucosal immune system and can delay the development of autoimmune diabetes. This result has important implications for the development of probiotic treatment for T1D. Twit Text FOAVip Long Term Effect of Gut Microbiota Transfer on Diabetes Development ????J Autoimmun http://www.kidney.de/pget.php?&tw=1&pmid=24767831 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24767831 #FOAvip English Wikipedia <ref>{{Cite pmid|24767831}}</ref> Long Term Effect of Gut Microbiota Transfer on Diabetes Development #MMPMID24767831 Peng J; Narasimhan S; Marchesi JR; Benson A; Wong FS; Wen L J Autoimmun 2014[Sep]; 53 (ä): 85-94 PMID24767831show ga The composition of the gut microbiome represents a very important environmental factor that influences the development of type 1 diabetes (T1D). We have previously shown that MyD88-deficient non-obese diabetic (MyD88?/?NOD) mice, that were protected from T1D development, had a different composition of gut microbiota compared to wild type NOD mice. The aim of our study was to investigate whether this protection could be transferred. We demonstrate that transfer of gut microbiota from diabetes-protected MyD88-deficient NOD mice, reduced insulitis and significantly delayed the onset of diabetes. Gut bacteria from MyD88-deficient mice, administered over a 3-week period, starting at 4 weeks of age, stably altered the family composition of the gut microbiome, with principally Lachnospiraceae and Clostridiaceae increased and Lactobacillaceae decreased. The transferred mice had a higher concentration of IgA and TGF? in the lumen that was accompanied by an increase in CD8+CD103+ and CD8?? T cells in the lamina propria of the large intestine. These data indicate not only that gut bacterial composition can be altered after the neonatal/weaning period, but that the composition of the microbiome affects the mucosal immune system and can delay the development of autoimmune diabetes. This result has important implications for the development of probiotic treatment for T1D. äLong Term Effect of Gut Microbiota Transfer on Diabetes Development (epmc).pdf DeepDyve Pubget Overpricing