Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.celrep.2014.07.053 http://scihub22266oqcxt.onion/10.1016/j.celrep.2014.07.053 C4360961!4360961 !25176644     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25176644 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2014 ; 8 (5 ): 1461-74 Nephropedia Template TP {{tp|p=25176644 |t=2014. Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth |pdf=|usr=}}{{25176644 }} gab.com Text Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25176644 #FOAvip Accumulating evidence suggests that codeletion of the tumor suppressor genes Pten and p53 plays a crucial role in the development of castration-resistant prostate cancer in vivo. However, the molecular mechanism underlying Pten-/p53-deficiency-driven prostate tumorigenesis remains incompletely understood. Building upon insights gained from our studies with Pten-/p53-deficient mouse embryonic fibroblasts (MEFs), we report here that hexokinase 2 (HK2) is selectively upregulated by the combined loss of Pten and p53 in prostate cancer cells. Mechanistically, Pten deletion increases HK2 mRNA translation through the activation of the AKT-mTORC1-4EBP1 axis, and p53 loss enhances HK2 mRNA stability through the inhibition of miR143 biogenesis. Genetic studies demonstrate that HK2-mediated aerobic glycolysis, known as the Warburg effect, is required for Pten-/p53-deficiency-driven tumor growth in xenograft mouse models of prostate cancer. Our findings suggest that HK2 might be a therapeutic target for prostate cancer patients carrying Pten and p53 mutations. Twit Text FOAVip Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25176644 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25176644 #FOAvip English Wikipedia <ref>{{Cite pmid|25176644 }}</ref> Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth #MMPMID25176644 Wang L ; Xiong H ; Wu F ; Zhang Y ; Wang J ; Zhao L ; Guo X ; Chang LJ ; Zhang Y ; You MJ ; Koochekpour S ; Saleem M ; Huang H ; Lu J ; Deng Y Cell Rep 2014[Sep]; 8 (5 ): 1461-74 PMID25176644 show ga Accumulating evidence suggests that codeletion of the tumor suppressor genes Pten and p53 plays a crucial role in the development of castration-resistant prostate cancer in vivo. However, the molecular mechanism underlying Pten-/p53-deficiency-driven prostate tumorigenesis remains incompletely understood. Building upon insights gained from our studies with Pten-/p53-deficient mouse embryonic fibroblasts (MEFs), we report here that hexokinase 2 (HK2) is selectively upregulated by the combined loss of Pten and p53 in prostate cancer cells. Mechanistically, Pten deletion increases HK2 mRNA translation through the activation of the AKT-mTORC1-4EBP1 axis, and p53 loss enhances HK2 mRNA stability through the inhibition of miR143 biogenesis. Genetic studies demonstrate that HK2-mediated aerobic glycolysis, known as the Warburg effect, is required for Pten-/p53-deficiency-driven tumor growth in xenograft mouse models of prostate cancer. Our findings suggest that HK2 might be a therapeutic target for prostate cancer patients carrying Pten and p53 mutations. |*Glycolysis [MESH] |Adaptor Proteins, Signal Transducing [MESH] |Animals [MESH] |Carrier Proteins/metabolism [MESH] |Cell Cycle Proteins [MESH] |Cell Line, Tumor [MESH] |Eukaryotic Initiation Factors [MESH] |Fibroblasts/metabolism [MESH] |Gene Deletion [MESH] |Hexokinase/genetics/*metabolism [MESH] |Male [MESH] |Mechanistic Target of Rapamycin Complex 1 [MESH] |Mice [MESH] |Multiprotein Complexes/metabolism [MESH] |PTEN Phosphohydrolase/deficiency/*genetics/metabolism [MESH] |Phosphoproteins/metabolism [MESH] |Prostatic Neoplasms/genetics/*metabolism [MESH] |Protein Biosynthesis [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH] |RNA, Messenger/genetics/metabolism [MESH] |TOR Serine-Threonine Kinases/metabolism [MESH]Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-d(epmc).pdf DeepDyve Pubget Overpricing