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From plant extract to molecular panacea: a commentary on Stone (1763) An account
of the success of the bark of the willow in the cure of the agues
#MMPMID25750237
Wood JN
Philos Trans R Soc Lond B Biol Sci
2015[Apr]; 370
(1666
): ? PMID25750237
show ga
The application of aspirin-like drugs in modern medicine is very broad,
encompassing the treatment of inflammation, pain and a variety of cardiovascular
conditions. Although anecdotal accounts of willow bark extract as an
anti-inflammatory drug have occurred since written records began (for example by
Hippocrates), the first convincing demonstration of a potent anti-pyretic effect
of willow bark containing salicylates was made by the English cleric Edward Stone
in the late eighteenth century. Here, we discuss the route to optimizing and
understanding the mechanism of action of anti-inflammatory drugs that have their
origins in Stone's seminal study, 'An account of the success of the bark of the
willow in the cure of agues'. This commentary was written to celebrate the 350th
anniversary of the journal Philosophical Transactions of the Royal Society.
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