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10.1152/ajprenal.00516.2014 http://scihub22266oqcxt.onion/10.1152/ajprenal.00516.2014 C4360031!4360031!25608967     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2015 ; 308 (6): F650-60 Nephropedia Template TP {{tp|p=25608967|t=2015. Glycogen synthase kinase 3? regulates urine concentrating mechanism in mice |pdf=|usr=}}{{25608967}} gab.com Text Glycogen synthase kinase 3 regulates urine concentrating mechanism in mice JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25608967 #FOAvip In mammals, glycogen synthase kinase (GSK)3 comprises GSK3? and GSK3? isoforms. GSK3? has been shown to play a role in the ability of kidneys to concentrate urine by regulating vasopressin-mediated water permeability of collecting ducts, whereas the role of GSK3? has yet to be discerned. To investigate the role of GSK3? in urine concentration, we compared GSK3? knockout (GSK3?KO) mice with wild-type (WT) littermates. Under normal conditions, GSK3?KO mice had higher water intake and urine output. GSK3?KO mice also showed reduced urine osmolality and aquaporin-2 levels but higher urinary vasopressin. When water deprived, they failed to concentrate their urine to the same level as WT littermates. The addition of 1-desamino-8-d-arginine vasopressin to isolated inner medullary collecting ducts increased the cAMP response in WT mice, but this response was reduced in GSK3?KO mice, suggesting reduced responsiveness to vasopressin. Gene silencing of GSK3? in mpkCCD cells also reduced forskolin-induced aquaporin-2 expression. When treated with LiCl, an isoform nonselective inhibitor of GSK3 and known inducer of polyuria, WT mice developed significant polyuria within 6 days. However, in GSK3?KO mice, the polyuric response was markedly reduced. This study demonstrates, for the first time, that GSK3? could play a crucial role in renal urine concentration and suggest that GSK3? might be one of the initial targets of Li+ in LiCl-induced nephrogenic diabetes insipidus. Twit Text FOAVip Glycogen synthase kinase 3 regulates urine concentrating mechanism in mice ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25608967 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25608967 #FOAvip English Wikipedia <ref>{{Cite pmid|25608967}}</ref> Glycogen synthase kinase 3? regulates urine concentrating mechanism in mice #MMPMID25608967 Nørregaard R; Tao S; Nilsson L; Woodgett JR; Kakade V; Yu ASL; Howard C; Rao R Am J Physiol Renal Physiol 2015[Mar]; 308 (6): F650-60 PMID25608967show ga In mammals, glycogen synthase kinase (GSK)3 comprises GSK3? and GSK3? isoforms. GSK3? has been shown to play a role in the ability of kidneys to concentrate urine by regulating vasopressin-mediated water permeability of collecting ducts, whereas the role of GSK3? has yet to be discerned. To investigate the role of GSK3? in urine concentration, we compared GSK3? knockout (GSK3?KO) mice with wild-type (WT) littermates. Under normal conditions, GSK3?KO mice had higher water intake and urine output. GSK3?KO mice also showed reduced urine osmolality and aquaporin-2 levels but higher urinary vasopressin. When water deprived, they failed to concentrate their urine to the same level as WT littermates. The addition of 1-desamino-8-d-arginine vasopressin to isolated inner medullary collecting ducts increased the cAMP response in WT mice, but this response was reduced in GSK3?KO mice, suggesting reduced responsiveness to vasopressin. Gene silencing of GSK3? in mpkCCD cells also reduced forskolin-induced aquaporin-2 expression. When treated with LiCl, an isoform nonselective inhibitor of GSK3 and known inducer of polyuria, WT mice developed significant polyuria within 6 days. However, in GSK3?KO mice, the polyuric response was markedly reduced. This study demonstrates, for the first time, that GSK3? could play a crucial role in renal urine concentration and suggest that GSK3? might be one of the initial targets of Li+ in LiCl-induced nephrogenic diabetes insipidus. äGlycogen synthase kinase 3? regulates urine concentrating mechanism in(epmc).pdf DeepDyve Pubget Overpricing