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10.1097/PAS.0000000000000377 http://scihub22266oqcxt.onion/10.1097/PAS.0000000000000377 C4359621!4359621!25602792     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25602792.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Surg+Pathol 2015 ; 39 (4): 549-57 Nephropedia Template TP {{tp|p=25602792|t=2015. Molecular and immunohistochemical characterization reveals novel BRAF mutations in metanephric adenoma |pdf=|usr=}}{{25602792}} gab.com Text Molecular and immunohistochemical characterization reveals novel BRAF mutations in metanephric adenoma JO: Am J Surg Pathol http://www.kidney.de/pget.php?&tw=1&pmid=25602792 #FOAvip Metanephric adenoma (MA) is a rare benign renal tumor comprised of a neoplastic proliferation of primitive metanephric tubular cells. A previous study identified BRAF V600E mutations in approximately 90% of MA and found that similar BRAF exon 15 mutations are exceedingly rare in other common renal tumors, including renal cell carcinoma (RCC) and oncocytoma. A recent follow-up study has validated mutation-specific immunohistochemistry (IHC) for detection of BRAF V600E mutations in a small cohort of MA. Here, we extend these findings to a larger, independent cohort of MA, demonstrating an overall 88% sensitivity and 100% specificity for BRAF V600E IHC. In addition, we report two cases of MA with novel BRAF exon 15 mutations, including a V600D missense mutation and a compound V600D and K601L missense mutation. Finally, we evaluate BRAF V600E IHC in a large TMA cohort of common renal tumors and find no significant expression in several RCC subtypes. These data support a role for BRAF V600E IHC in diagnostically challenging cases of MA and expand the spectrum of BRAF exon 15 mutations in this uncommon but unique renal neoplasm. Twit Text FOAVip Molecular and immunohistochemical characterization reveals novel BRAF mutations in metanephric adenoma ????Am J Surg Pathol http://www.kidney.de/pget.php?&tw=1&pmid=25602792 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25602792 #FOAvip English Wikipedia <ref>{{Cite pmid|25602792}}</ref> Molecular and immunohistochemical characterization reveals novel BRAF mutations in metanephric adenoma #MMPMID25602792 Udager AM; Pan J; Magers MJ; Palapattu GS; Morgan TM; Montgomery JS; Weizer AZ; Hafez KS; Miller DC; Wolf JS; McHugh JB; Chinnaiyan AM; Dhanasekaran SM; Mehra R Am J Surg Pathol 2015[Apr]; 39 (4): 549-57 PMID25602792show ga Metanephric adenoma (MA) is a rare benign renal tumor comprised of a neoplastic proliferation of primitive metanephric tubular cells. A previous study identified BRAF V600E mutations in approximately 90% of MA and found that similar BRAF exon 15 mutations are exceedingly rare in other common renal tumors, including renal cell carcinoma (RCC) and oncocytoma. A recent follow-up study has validated mutation-specific immunohistochemistry (IHC) for detection of BRAF V600E mutations in a small cohort of MA. Here, we extend these findings to a larger, independent cohort of MA, demonstrating an overall 88% sensitivity and 100% specificity for BRAF V600E IHC. In addition, we report two cases of MA with novel BRAF exon 15 mutations, including a V600D missense mutation and a compound V600D and K601L missense mutation. Finally, we evaluate BRAF V600E IHC in a large TMA cohort of common renal tumors and find no significant expression in several RCC subtypes. These data support a role for BRAF V600E IHC in diagnostically challenging cases of MA and expand the spectrum of BRAF exon 15 mutations in this uncommon but unique renal neoplasm. äMolecular and immunohistochemical characterization reveals novel BRAF (epmc).pdf DeepDyve Pubget Overpricing