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10.1161/HYPERTENSIONAHA.114.04760 http://scihub22266oqcxt.onion/10.1161/HYPERTENSIONAHA.114.04760 C4359100!4359100!25691623     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25691623.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Hypertension 2015 ; 65 (4): 896-902 Nephropedia Template TP {{tp|p=25691623|t=2015. ACTIVATION OF NRF2 COORDINATES DDAH/PPAR-?/eNOS PATHWAYS THAT ENHANCE NITRIC OXIDE GENERATION IN HUMAN GLOMERULAR ENDOTHELIAL CELLS |pdf=|usr=}}{{25691623}} gab.com Text ACTIVATION OF NRF2 COORDINATES DDAH/PPAR- /eNOS PATHWAYS THAT ENHANCE NITRIC OXIDE GENERATION IN HUMAN GLOMERULAR ENDOTHELIAL CELLS JO: Hypertension http://www.kidney.de/pget.php?&tw=1&pmid=25691623 #FOAvip Dimethylarginine dimethylaminohydrolase (DDAH) degrades (ADMA) which inhibits nitric oxide synthase (NOS). Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcriptional factor that binds to antioxidant response elements (ARE) and transcribes many antioxidant genes. Since the promoters of the human DDAH-1 and -2, eNOS and PPAR- ? genes contain 2?3 putative AREs, we hypothesized that they were regulated by Nrf2/ARE. Incubation of human renal glomerular endothelial cells (HRGECs) with the Nrf2 activator tert-butylhydroquinone (tBHQ) (20 µmol?l?1) significantly (P<0.05) increased NO and activities of NOS and DDAH and decreased ADMA. It upregulated genes for hemoxygenase -1, eNOS, DDAH-1 and -2 and PPAR-? and partitioned Nrf2 into the nucleus. Knockdown of Nrf2 abolished these effects. Nrf2 bound to one ARE on the DDAH-1 and -2 and PPAR-? promoters but not to the eNOS promoter. An increased eNOS and phosphorylated eNOS (P-eNOSser-1177) expression with tBHQ was prevented by knockdown of PPAR-?. Expression of Nrf2 was reduced by knockdown of PPAR-? whereas PPAR-? was reduced by knockdown of Nrf2, thereby demonstrating 2-way positive interactions. Thus, Nrf2 transcribes the HO-1 and other genes to reduce reactive oxygen species, and DDAH-1 and -2 to reduce ADMA and PPAR-? to increase eNOS and its phosphorylation and activity thereby coordinating three pathways that enhance endothelial NO generation. Twit Text FOAVip ACTIVATION OF NRF2 COORDINATES DDAH/PPAR- /eNOS PATHWAYS THAT ENHANCE NITRIC OXIDE GENERATION IN HUMAN GLOMERULAR ENDOTHELIAL CELLS ????Hypertension http://www.kidney.de/pget.php?&tw=1&pmid=25691623 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25691623 #FOAvip English Wikipedia <ref>{{Cite pmid|25691623}}</ref> ACTIVATION OF NRF2 COORDINATES DDAH/PPAR-?/eNOS PATHWAYS THAT ENHANCE NITRIC OXIDE GENERATION IN HUMAN GLOMERULAR ENDOTHELIAL CELLS #MMPMID25691623 Luo Z; Aslam S; Welch WJ; Wilcox CS Hypertension 2015[Apr]; 65 (4): 896-902 PMID25691623show ga Dimethylarginine dimethylaminohydrolase (DDAH) degrades (ADMA) which inhibits nitric oxide synthase (NOS). Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcriptional factor that binds to antioxidant response elements (ARE) and transcribes many antioxidant genes. Since the promoters of the human DDAH-1 and -2, eNOS and PPAR- ? genes contain 2?3 putative AREs, we hypothesized that they were regulated by Nrf2/ARE. Incubation of human renal glomerular endothelial cells (HRGECs) with the Nrf2 activator tert-butylhydroquinone (tBHQ) (20 µmol?l?1) significantly (P<0.05) increased NO and activities of NOS and DDAH and decreased ADMA. It upregulated genes for hemoxygenase -1, eNOS, DDAH-1 and -2 and PPAR-? and partitioned Nrf2 into the nucleus. Knockdown of Nrf2 abolished these effects. Nrf2 bound to one ARE on the DDAH-1 and -2 and PPAR-? promoters but not to the eNOS promoter. An increased eNOS and phosphorylated eNOS (P-eNOSser-1177) expression with tBHQ was prevented by knockdown of PPAR-?. Expression of Nrf2 was reduced by knockdown of PPAR-? whereas PPAR-? was reduced by knockdown of Nrf2, thereby demonstrating 2-way positive interactions. Thus, Nrf2 transcribes the HO-1 and other genes to reduce reactive oxygen species, and DDAH-1 and -2 to reduce ADMA and PPAR-? to increase eNOS and its phosphorylation and activity thereby coordinating three pathways that enhance endothelial NO generation. äACTIVATION OF NRF2 COORDINATES DDAH/PPAR-?/eNOS PATHWAYS THAT ENHANCE (epmc).pdf DeepDyve Pubget Overpricing