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10.1111/ctr.12514 http://scihub22266oqcxt.onion/10.1111/ctr.12514 C4359066!4359066 !25619874     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25619874 &cmd=llinks): Failed to open stream: HTTP request failed! 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Daily fluid intake and outcomes in kidney recipients: post hoc analysis from the randomized ABCAN trial |pdf=|usr=}}{{25619874 }} gab.com Text Daily fluid intake and outcomes in kidney recipients: post hoc analysis from the randomized ABCAN trial JO: Clin Transplant http://www.kidney.de/pget.php?&tw=1&pmid=25619874 #FOAvip Generous and even excessive fluid intake is routinely recommended to kidney transplant recipients despite minimal evidence to support this practice. We hypothesized that increased fluid intake, ascertained by 24-h urine volume output, may adversely affect graft outcomes as it would impose an extra workload on a limited number of nephrons. Kidney transplant recipients who were randomized to losartan vs. placebo in the Angiotensin II Blockade for Chronic Allograft Nephropathy (ABCAN) trial (n = 153) underwent baseline, five-yr biopsies, and annual iothalamate glomerular filtration rate assessment. Recipients with higher urine volume at randomization had higher urinary sodium and also higher urinary protein. The proportion using diuretics or CNI based regimens were similar across urinary volume tertiles. The highest urinary volume tertile (>2.56 L/d) did not predict the development of interstitial volume doubling or end-stage renal disease (ESRD) from interstitial fibrosis/tubular atrophy (OR = 3.52, 95% CI 0.4, 31.24, p = 0.26), interstitial volume doubling or all-cause ESRD (OR = 7.04, 95% CI 0.66, 74.87, p = 0.11), and was not associated with the conventional endpoint of doubling serum creatinine, all-cause ESRD, or death (OR = 0.89, 95% CI 0.21, 3.71, p = 0.87). These results suggest that the current practice of liberal fluid intake may not be beneficial in low risk and mostly Caucasian transplant recipients. Twit Text FOAVip Daily fluid intake and outcomes in kidney recipients: post hoc analysis from the randomized ABCAN trial ????Clin Transplant http://www.kidney.de/pget.php?&tw=1&pmid=25619874 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25619874 #FOAvip English Wikipedia <ref>{{Cite pmid|25619874 }}</ref> Daily fluid intake and outcomes in kidney recipients: post hoc analysis from the randomized ABCAN trial #MMPMID25619874 Weber M ; Berglund D ; Reule S ; Jackson S ; Matas AJ ; Ibrahim HN Clin Transplant 2015[Mar]; 29 (3 ): 261-7 PMID25619874 show ga Generous and even excessive fluid intake is routinely recommended to kidney transplant recipients despite minimal evidence to support this practice. We hypothesized that increased fluid intake, ascertained by 24-h urine volume output, may adversely affect graft outcomes as it would impose an extra workload on a limited number of nephrons. Kidney transplant recipients who were randomized to losartan vs. placebo in the Angiotensin II Blockade for Chronic Allograft Nephropathy (ABCAN) trial (n = 153) underwent baseline, five-yr biopsies, and annual iothalamate glomerular filtration rate assessment. Recipients with higher urine volume at randomization had higher urinary sodium and also higher urinary protein. The proportion using diuretics or CNI based regimens were similar across urinary volume tertiles. The highest urinary volume tertile (>2.56 L/d) did not predict the development of interstitial volume doubling or end-stage renal disease (ESRD) from interstitial fibrosis/tubular atrophy (OR = 3.52, 95% CI 0.4, 31.24, p = 0.26), interstitial volume doubling or all-cause ESRD (OR = 7.04, 95% CI 0.66, 74.87, p = 0.11), and was not associated with the conventional endpoint of doubling serum creatinine, all-cause ESRD, or death (OR = 0.89, 95% CI 0.21, 3.71, p = 0.87). These results suggest that the current practice of liberal fluid intake may not be beneficial in low risk and mostly Caucasian transplant recipients. |*Kidney Transplantation [MESH] |Adult [MESH] |Aged [MESH] |Drinking Behavior/*physiology [MESH] |Drinking/*physiology [MESH] |Female [MESH] |Follow-Up Studies [MESH] |Glomerular Filtration Rate [MESH] |Graft Survival [MESH] |Humans [MESH] |Kidney Failure, Chronic/physiopathology/*surgery [MESH] |Male [MESH] |Middle Aged [MESH] |Postoperative Period [MESH] |Prospective Studies [MESH] |Recurrence [MESH] |Treatment Outcome [MESH]Daily fluid intake and outcomes in kidney recipients: post hoc analysi(epmc).pdf DeepDyve Pubget Overpricing