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10.1016/j.tibs.2014.04.004 http://scihub22266oqcxt.onion/10.1016/j.tibs.2014.04.004 C4358807!4358807!24818748     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Biochem+Sci 2014 ; 39 (6): 268-76 Nephropedia Template TP {{tp|p=24818748|t=2014. Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence |pdf=|usr=}}{{24818748}} gab.com Text Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence JO: Trends Biochem Sci http://www.kidney.de/pget.php?&tw=1&pmid=24818748 #FOAvip Oncogene-induced senescence (OIS) is a tumor-suppressing response that must be disrupted for cancer to develop. Mechanistic insights into OIS have begun to emerge. Activation of the p53/p21WAF1 and/or p16INK4A tumor-suppressor pathways is essential for OIS. Moreover, the DNA damage response, chromatin remodeling and senescence-associated secretory phenotype (SASP) are important for the initiation and maintenance of OIS. This review discusses recent advances in elucidating the mechanisms of OIS, focusing on the roles of the p38 MAPK and PI3K/AKT/mTOR pathways. These studies indicate that OIS is mediated by an intricate signaling network. Further delineation of this network may lead to development of new cancer therapies targeting OIS. Twit Text FOAVip Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence ????Trends Biochem Sci http://www.kidney.de/pget.php?&tw=1&pmid=24818748 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24818748 #FOAvip English Wikipedia <ref>{{Cite pmid|24818748}}</ref> Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence #MMPMID24818748 Xu Y; Li N; Xiang R; Sun P Trends Biochem Sci 2014[Jun]; 39 (6): 268-76 PMID24818748show ga Oncogene-induced senescence (OIS) is a tumor-suppressing response that must be disrupted for cancer to develop. Mechanistic insights into OIS have begun to emerge. Activation of the p53/p21WAF1 and/or p16INK4A tumor-suppressor pathways is essential for OIS. Moreover, the DNA damage response, chromatin remodeling and senescence-associated secretory phenotype (SASP) are important for the initiation and maintenance of OIS. This review discusses recent advances in elucidating the mechanisms of OIS, focusing on the roles of the p38 MAPK and PI3K/AKT/mTOR pathways. These studies indicate that OIS is mediated by an intricate signaling network. Further delineation of this network may lead to development of new cancer therapies targeting OIS. äEmerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-(epmc).pdf DeepDyve Pubget Overpricing