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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Protoc+Mouse+Biol
2015 ; 5
(1
): 21-34
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gab.com Text
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English Wikipedia
Overview of biological mechanisms and applications of three murine models of bone
repair: closed fracture with intramedullary fixation, distraction osteogenesis,
and marrow ablation by reaming
#MMPMID25727198
Bragdon B
; Lybrand K
; Gerstenfeld L
Curr Protoc Mouse Biol
2015[Mar]; 5
(1
): 21-34
PMID25727198
show ga
Fractures are one of the most common large-organ, traumatic injuries in humans,
and osteoporosis-related fractures are the fastest growing health care problem of
aging. Elective orthopedic surgeries of the bones and joints also represent some
of most common forms of elective surgeries performed. Optimal repair of skeletal
tissues is necessary for successful outcomes of these many different orthopedic
surgical treatments. Research focused on post-natal skeletal repair is therefore
of immense clinical importance and of particular relevance in situations in which
bone tissue healing is compromised due to the extent of tissue trauma or specific
medical co-morbidities. Three commonly used murine surgical models of bone
healing, closed fracture with intramedullary fixation, distraction osteogenesis
(DO), and marrow ablation by reaming, are presented. The biological aspects of
these models are contrasted and the types of research questions that may be
addressed with these models are presented.