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10.1113/jphysiol.2014.284240 http://scihub22266oqcxt.onion/10.1113/jphysiol.2014.284240 C4358679!4358679 !25557265     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25557265 &cmd=llinks): Failed to open stream: HTTP request failed! 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Visually induced nausea causes characteristic changes in cerebral, autonomic and endocrine function in humans |pdf=|usr=}}{{25557265 }} gab.com Text Visually induced nausea causes characteristic changes in cerebral, autonomic and endocrine function in humans JO: J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25557265 #FOAvip An integrated understanding of the physiological mechanisms involved in the genesis of nausea remains lacking. We aimed to describe the psychophysiological changes accompanying visually induced motion sickness, using a motion video, hypothesizing that differences would be evident between subjects who developed nausea in comparison to those who did not. A motion, or a control, stimulus was presented to 98 healthy subjects in a randomized crossover design. Validated questionnaires and a visual analogue scale (VAS) were used for the assessment of anxiety and nausea. Autonomic and electrogastrographic activity were measured at baseline and continuously thereafter. Plasma vasopressin and ghrelin were measured in response to the motion video. Subjects were stratified into quartiles based on VAS nausea scores, with the upper and lower quartiles considered to be nausea sensitive and resistant, respectively. Twenty-eight subjects were exposed to the motion video during functional neuroimaging. During the motion video, nausea-sensitive subjects had lower normogastria/tachygastria ratio and cardiac vagal tone but higher cardiac sympathetic index in comparison to the control video. Furthermore, nausea-sensitive subjects had decreased plasma ghrelin and demonstrated increased activity of the left anterior cingulate cortex. Nausea VAS scores correlated positively with plasma vasopressin and left inferior frontal and middle occipital gyri activity and correlated negatively with plasma ghrelin and brain activity in the right cerebellar tonsil, declive, culmen, lingual gyrus and cuneus. This study demonstrates that the subjective sensation of nausea is associated with objective changes in autonomic, endocrine and brain networks, and thus identifies potential objective biomarkers and targets for therapeutic interventions. Twit Text FOAVip Visually induced nausea causes characteristic changes in cerebral, autonomic and endocrine function in humans ????J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25557265 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25557265 #FOAvip English Wikipedia <ref>{{Cite pmid|25557265 }}</ref> Visually induced nausea causes characteristic changes in cerebral, autonomic and endocrine function in humans #MMPMID25557265 Farmer AD ; Ban VF ; Coen SJ ; Sanger GJ ; Barker GJ ; Gresty MA ; Giampietro VP ; Williams SC ; Webb DL ; Hellström PM ; Andrews PL ; Aziz Q J Physiol 2015[Mar]; 593 (5 ): 1183-96 PMID25557265 show ga An integrated understanding of the physiological mechanisms involved in the genesis of nausea remains lacking. We aimed to describe the psychophysiological changes accompanying visually induced motion sickness, using a motion video, hypothesizing that differences would be evident between subjects who developed nausea in comparison to those who did not. A motion, or a control, stimulus was presented to 98 healthy subjects in a randomized crossover design. Validated questionnaires and a visual analogue scale (VAS) were used for the assessment of anxiety and nausea. Autonomic and electrogastrographic activity were measured at baseline and continuously thereafter. Plasma vasopressin and ghrelin were measured in response to the motion video. Subjects were stratified into quartiles based on VAS nausea scores, with the upper and lower quartiles considered to be nausea sensitive and resistant, respectively. Twenty-eight subjects were exposed to the motion video during functional neuroimaging. During the motion video, nausea-sensitive subjects had lower normogastria/tachygastria ratio and cardiac vagal tone but higher cardiac sympathetic index in comparison to the control video. Furthermore, nausea-sensitive subjects had decreased plasma ghrelin and demonstrated increased activity of the left anterior cingulate cortex. Nausea VAS scores correlated positively with plasma vasopressin and left inferior frontal and middle occipital gyri activity and correlated negatively with plasma ghrelin and brain activity in the right cerebellar tonsil, declive, culmen, lingual gyrus and cuneus. This study demonstrates that the subjective sensation of nausea is associated with objective changes in autonomic, endocrine and brain networks, and thus identifies potential objective biomarkers and targets for therapeutic interventions. |Adult [MESH] |Autonomic Nervous System/*physiology [MESH] |Case-Control Studies [MESH] |Cerebral Cortex/*physiology [MESH] |Endocrine System/*physiology [MESH] |Female [MESH] |Ghrelin/blood [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |Motion Sickness/blood/*physiopathology [MESH] |Nausea/blood/*physiopathology [MESH]Visually induced nausea causes characteristic changes in cerebral, aut(epmc).pdf DeepDyve Pubget Overpricing