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10.1101/gad.254151.114 http://scihub22266oqcxt.onion/10.1101/gad.254151.114 C4358400!4358400 !25737277     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25737277 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Genes+Dev 2015 ; 29 (5 ): 483-8 Nephropedia Template TP {{tp|p=25737277 |t=2015. A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth |pdf=|usr=}}{{25737277 }} gab.com Text A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=25737277 #FOAvip We performed a genome-scale shRNA screen for modulators of B-cell leukemia progression in vivo. Results from this work revealed dramatic distinctions between the relative effects of shRNAs on the growth of tumor cells in culture versus in their native microenvironment. Specifically, we identified many "context-specific" regulators of leukemia development. These included the gene encoding the zinc finger protein Phf6. While inactivating mutations in PHF6 are commonly observed in human myeloid and T-cell malignancies, we found that Phf6 suppression in B-cell malignancies impairs tumor progression. Thus, Phf6 is a "lineage-specific" cancer gene that plays opposing roles in developmentally distinct hematopoietic malignancies. Twit Text FOAVip A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=25737277 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25737277 #FOAvip English Wikipedia <ref>{{Cite pmid|25737277 }}</ref> A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth #MMPMID25737277 Meacham CE ; Lawton LN ; Soto-Feliciano YM ; Pritchard JR ; Joughin BA ; Ehrenberger T ; Fenouille N ; Zuber J ; Williams RT ; Young RA ; Hemann MT Genes Dev 2015[Mar]; 29 (5 ): 483-8 PMID25737277 show ga We performed a genome-scale shRNA screen for modulators of B-cell leukemia progression in vivo. Results from this work revealed dramatic distinctions between the relative effects of shRNAs on the growth of tumor cells in culture versus in their native microenvironment. Specifically, we identified many "context-specific" regulators of leukemia development. These included the gene encoding the zinc finger protein Phf6. While inactivating mutations in PHF6 are commonly observed in human myeloid and T-cell malignancies, we found that Phf6 suppression in B-cell malignancies impairs tumor progression. Thus, Phf6 is a "lineage-specific" cancer gene that plays opposing roles in developmentally distinct hematopoietic malignancies. |Carrier Proteins/*genetics/*metabolism [MESH] |Cell Lineage [MESH] |Cell Proliferation/genetics [MESH] |Genome, Human/genetics [MESH] |Humans [MESH] |Leukemia/*genetics/physiopathology [MESH] |Mutation/genetics [MESH] |RNA, Small Interfering/genetics [MESH]A genome-scale in vivo loss-of-function screen identifies Phf6 as a (epmc).pdf DeepDyve Pubget Overpricing