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10.1074/jbc.M114.617886

http://scihub22266oqcxt.onion/10.1074/jbc.M114.617886
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C4358290!4358290!25596528
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suck abstract from ncbi


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pmid25596528      J+Biol+Chem 2015 ; 290 (10): 6574-83
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  • Inflammation and Pyroptosis Mediate Muscle Expansion in an Interleukin-1? (IL-1?)-dependent Manner* #MMPMID25596528
  • Haldar S; Dru C; Choudhury D; Mishra R; Fernandez A; Biondi S; Liu Z; Shimada K; Arditi M; Bhowmick NA
  • J Biol Chem 2015[Mar]; 290 (10): 6574-83 PMID25596528show ga
  • Background: Hyperplasia is a common phenomenon in inflamed muscle.Results: IL-1? secreted associated with pyroptotic cell death mediate IGF1-dependent detrusor expansion.Conclusion: Bladder muscle hyperplasia resulting from NLRP3 inflammatory cascade can be attenuated by neutralization of IL-1? and IGF1.Significance: Antagonizing IL-1? can have a therapeutic benefit for subjects with muscle hyperplasia resulting from chronic inflammatory diseases.
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