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10.1074/jbc.M114.602979

http://scihub22266oqcxt.onion/10.1074/jbc.M114.602979
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C4358264!4358264!25589784
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suck abstract from ncbi


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pmid25589784      J+Biol+Chem 2015 ; 290 (10): 6270-80
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  • Anoctamin-6 Controls Bone Mineralization by Activating the Calcium Transporter NCX1* #MMPMID25589784
  • Ousingsawat J; Wanitchakool P; Schreiber R; Wuelling M; Vortkamp A; Kunzelmann K
  • J Biol Chem 2015[Mar]; 290 (10): 6270-80 PMID25589784show ga
  • Background: Deletion of Ano6 leads to reduced skeleton size and skeletal deformities.Results: Ca2+-activated anion currents are missing in primary osteoblasts from Ano6 null mice. Ano6 is required for the Na+/Ca2+ exchanger NCX1 to operate in osteoblasts.Conclusion: The Na+/Ca2+ exchanger NCX1 is essential for bone mineralization and requires Ano6 to fully operate.Significance: Ano6 supports NCX1, which is essential for bone mineralization.
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