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10.1074/jbc.M114.624411

http://scihub22266oqcxt.onion/10.1074/jbc.M114.624411
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C4358258!4358258!25605730
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suck abstract from ncbi


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pmid25605730      J+Biol+Chem 2015 ; 290 (10): 6191-202
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  • Oncoprotein YAP Regulates the Spindle Checkpoint Activation in a Mitotic Phosphorylation-dependent Manner through Up-regulation of BubR1* #MMPMID25605730
  • Yang S; Zhang L; Chen X; Chen Y; Dong J
  • J Biol Chem 2015[Mar]; 290 (10): 6191-202 PMID25605730show ga
  • Background: Oncoprotein YAP regulates cell proliferation and tumorigenesis, and a cellular function of YAP in mitosis is largely unknown.Results: YAP and its mitotic phosphorylation regulate the spindle checkpoint through up-regulation of BubR1.Conclusion: The findings reveal a novel link between YAP and the spindle checkpoint.Significance: Our studies indicate a potential mechanism underlying the oncogenic function of YAP through dysregulation of the spindle checkpoint.
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