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10.1074/jbc.M114.597492

http://scihub22266oqcxt.onion/10.1074/jbc.M114.597492
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C4358142!4358142!25616664
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suck abstract from ncbi


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pmid25616664      J+Biol+Chem 2015 ; 290 (11): 7234-46
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  • Autophagy Enhances Intestinal Epithelial Tight Junction Barrier Function by Targeting Claudin-2 Protein Degradation* #MMPMID25616664
  • Nighot PK; Hu CAA; Ma TY
  • J Biol Chem 2015[Mar]; 290 (11): 7234-46 PMID25616664show ga
  • Background: How autophagy, a cell survival mechanism, regulates intestinal epithelial tight junction barrier or paracellular permeability is unknown.Results: Autophagy reduces the paracellular permeability of small solutes and ions via degradation of the pore-forming tight junction protein claudin-2.Conclusion: Autophagy enhances tight junction barrier function by targeting claudin-2.Significance: This is the first report showing autophagy regulation of the intestinal tight junction barrier.
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