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10.1074/jbc.M114.610915

http://scihub22266oqcxt.onion/10.1074/jbc.M114.610915
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suck abstract from ncbi


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pmid25605728      J+Biol+Chem 2015 ; 290 (11): 6857-67
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  • Long Non-coding RNAs (LncRNA) Regulated by Transforming Growth Factor (TGF) ?: LncRNA-HIT-MEDIATED TGF?-INDUCED EPITHELIAL TO MESENCHYMAL TRANSITION IN MAMMARY EPITHELIA* #MMPMID25605728
  • Richards EJ; Zhang G; Li ZP; Permuth-Wey J; Challa S; Li Y; Kong W; Dan S; Bui MM; Coppola D; Mao WM; Sellers TA; Cheng JQ
  • J Biol Chem 2015[Mar]; 290 (11): 6857-67 PMID25605728show ga
  • Background: Long noncoding RNAs (LncRNA) are emerging as key regulators in various biological processes. However, their role in epithelial-to-mesenchymal transition (EMT) remains elusive.Results: A subset of lncRNAs are dysregulated upon transforming growth factor (TGF) ?-induced EMT, and lncRNA-HIT mediates this process.Conclusion: LncRNAs such as lncRNA-HIT ((HOXA transcript induced by TGF?) play a pivotal role in EMT and breast cancer progression.Significance: Here we profiled lncRNAs in TGF?-induced EMT and identified a novel conserved lncRNA-HIT.
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