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10.1074/jbc.M114.610915 http://scihub22266oqcxt.onion/10.1074/jbc.M114.610915 C4358111!4358111 !25605728     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25605728 &cmd=llinks): Failed to open stream: HTTP request failed! 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Long non-coding RNAs (LncRNA) regulated by transforming growth factor (TGF) ?: LncRNA-hit-mediated TGF?-induced epithelial to mesenchymal transition in mammary epithelia |pdf=|usr=}}{{25605728 }} gab.com Text Long non-coding RNAs (LncRNA) regulated by transforming growth factor (TGF) : LncRNA-hit-mediated TGF -induced epithelial to mesenchymal transition in mammary epithelia JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25605728 #FOAvip Long noncoding RNAs (lncRNAs) are emerging as key regulators in various biological processes. Epithelial-to-mesenchymal transition (EMT) is a developmental process hijacked by tumor cells to depart from the primary tumor site, invade surrounding tissue, and establish distant metastases. Transforming growth factor ? (TGF?) signaling has been shown to be a major inducer of EMT and to facilitate breast cancer metastasis. However, the role of lncRNAs in this process remains largely unknown. Here we report a genome-wide lncRNA profile in mouse mammary epithelial NMuMG cells upon TGF? induction of EMT. Among 10,802 lncRNAs profiled, over 600 were up-regulated and down-regulated during the EMT, respectively. Furthermore, we identify that lncRNA-HIT (HOXA transcript induced by TGF?) mediates TGF? function, i.e. depletion of lncRNA-HIT inhibits TGF?-induced migration, invasion, and EMT in NMuMG. LncRNA-HIT is also significantly elevated in the highly metastatic 4T1 cells. Knockdown of lncRNA-HIT in 4T1 results in decrease of cell migration, invasion, tumor growth, and metastasis. E-cadherin was identified as a major target of lncRNA-HIT. Moreover, lncRNA-HIT is conserved in humans and elevated expression associates with more invasive human primary breast carcinoma. Collectively, these data suggest that a subset of lncRNAs such as lncRNA-HIT play a significant role in regulation of EMT and breast cancer invasion and metastasis, and could be potential therapeutic targets in breast cancers. Twit Text FOAVip Long non-coding RNAs (LncRNA) regulated by transforming growth factor (TGF) : LncRNA-hit-mediated TGF -induced epithelial to mesenchymal transition in mammary epithelia ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25605728 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25605728 #FOAvip English Wikipedia <ref>{{Cite pmid|25605728 }}</ref> Long non-coding RNAs (LncRNA) regulated by transforming growth factor (TGF) ?: LncRNA-hit-mediated TGF?-induced epithelial to mesenchymal transition in mammary epithelia #MMPMID25605728 Richards EJ ; Zhang G ; Li ZP ; Permuth-Wey J ; Challa S ; Li Y ; Kong W ; Dan S ; Bui MM ; Coppola D ; Mao WM ; Sellers TA ; Cheng JQ J Biol Chem 2015[Mar]; 290 (11 ): 6857-67 PMID25605728 show ga Long noncoding RNAs (lncRNAs) are emerging as key regulators in various biological processes. Epithelial-to-mesenchymal transition (EMT) is a developmental process hijacked by tumor cells to depart from the primary tumor site, invade surrounding tissue, and establish distant metastases. Transforming growth factor ? (TGF?) signaling has been shown to be a major inducer of EMT and to facilitate breast cancer metastasis. However, the role of lncRNAs in this process remains largely unknown. Here we report a genome-wide lncRNA profile in mouse mammary epithelial NMuMG cells upon TGF? induction of EMT. Among 10,802 lncRNAs profiled, over 600 were up-regulated and down-regulated during the EMT, respectively. Furthermore, we identify that lncRNA-HIT (HOXA transcript induced by TGF?) mediates TGF? function, i.e. depletion of lncRNA-HIT inhibits TGF?-induced migration, invasion, and EMT in NMuMG. LncRNA-HIT is also significantly elevated in the highly metastatic 4T1 cells. Knockdown of lncRNA-HIT in 4T1 results in decrease of cell migration, invasion, tumor growth, and metastasis. E-cadherin was identified as a major target of lncRNA-HIT. Moreover, lncRNA-HIT is conserved in humans and elevated expression associates with more invasive human primary breast carcinoma. Collectively, these data suggest that a subset of lncRNAs such as lncRNA-HIT play a significant role in regulation of EMT and breast cancer invasion and metastasis, and could be potential therapeutic targets in breast cancers. |*Epithelial-Mesenchymal Transition [MESH] |Animals [MESH] |Breast Neoplasms/genetics/metabolism/*pathology [MESH] |Breast/metabolism/*pathology [MESH] |Carcinoma, Ductal, Breast/genetics/metabolism/pathology [MESH] |Cell Line [MESH] |Epithelial Cells/metabolism/*pathology [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Lung Neoplasms/genetics/pathology/secondary [MESH] |Lung/metabolism/pathology [MESH] |Mice [MESH] |Neoplasm Invasiveness/*genetics/pathology [MESH] |RNA, Long Noncoding/*genetics/metabolism [MESH] |Transcriptome [MESH]Long non-coding RNAs (LncRNA) regulated by transforming growth factor (epmc).pdf DeepDyve Pubget Overpricing