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10.1074/jbc.M114.612648

http://scihub22266oqcxt.onion/10.1074/jbc.M114.612648
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C4358105!4358105!25605717
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suck abstract from ncbi


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pmid25605717      J+Biol+Chem 2015 ; 290 (11): 6789-98
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  • Systematic Mapping of WNT-FZD Protein Interactions Reveals Functional Selectivity by Distinct WNT-FZD Pairs* #MMPMID25605717
  • Dijksterhuis JP; Baljinnyam B; Stanger K; Sercan HO; Ji Y; Andres O; Rubin JS; Hannoush RN; Schulte G
  • J Biol Chem 2015[Mar]; 290 (11): 6789-98 PMID25605717show ga
  • Background: WNT-FZD specificity and signaling outcome have not been systematically mapped so far.Results: WNTs show selective binding to FZDs, and respective WNT-FZD pairs exert functional selectivity in different downstream signaling pathways.Conclusion: The WNT-FZD signaling system provides ligand-receptor selectivity.Significance: Understanding WNT-FZD selectivity is crucial for development of WNT pathway inhibitors and further understanding of molecular interactions within the WNT receptor signaling complex.
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