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10.1016/j.clim.2014.12.010 http://scihub22266oqcxt.onion/10.1016/j.clim.2014.12.010 C4357545!4357545!25572532     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Immunol 2015 ; 157 (1): 30-42 Nephropedia Template TP {{tp|p=25572532|t=2015. The Osteopontin Transgenic Mouse is a New Model for Sjögren?s Syndrome |pdf=|usr=}}{{25572532}} gab.com Text The Osteopontin Transgenic Mouse is a New Model for Sjögren s Syndrome JO: Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25572532 #FOAvip Osteopontin (Opn) is a cytokine involved in both physiological and pathological processes, and is elevated in many autoimmune diseases. Sjögren?s syndrome (SS) is an autoimmune disease with a strong female predilection characterized by lymphocytic infiltration of exocrine glands. We hypothesized Opn contributes to SS pathogenesis. We examined an established SS model, and found increased Opn locally and systemically. Next, we examined Opn transgenic (Opn Tg) mice for evidence of SS. Opn Tg animals exhibited lymphocytic infiltration of salivary and lacrimal glands, and Opn co-localized with the infiltrates. Moreover, saliva production was reduced, and SS autoantibodies were observed in the serum of these mice. Finally, female Opn Tg mice showed more severe disease compared to males. Taken together, these data support a role for Opn in SS pathogenesis. We identify a new model of spontaneous SS that recapitulates the human disease in terms of sex predilection, histopathology, salivary deficits, and autoantibodies. Twit Text FOAVip The Osteopontin Transgenic Mouse is a New Model for Sjögren s Syndrome ????Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25572532 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25572532 #FOAvip English Wikipedia <ref>{{Cite pmid|25572532}}</ref> The Osteopontin Transgenic Mouse is a New Model for Sjögren?s Syndrome #MMPMID25572532 Husain-Krautter S; Kramer JM; Li W; Guo B; Rothstein TL Clin Immunol 2015[Mar]; 157 (1): 30-42 PMID25572532show ga Osteopontin (Opn) is a cytokine involved in both physiological and pathological processes, and is elevated in many autoimmune diseases. Sjögren?s syndrome (SS) is an autoimmune disease with a strong female predilection characterized by lymphocytic infiltration of exocrine glands. We hypothesized Opn contributes to SS pathogenesis. We examined an established SS model, and found increased Opn locally and systemically. Next, we examined Opn transgenic (Opn Tg) mice for evidence of SS. Opn Tg animals exhibited lymphocytic infiltration of salivary and lacrimal glands, and Opn co-localized with the infiltrates. Moreover, saliva production was reduced, and SS autoantibodies were observed in the serum of these mice. Finally, female Opn Tg mice showed more severe disease compared to males. Taken together, these data support a role for Opn in SS pathogenesis. We identify a new model of spontaneous SS that recapitulates the human disease in terms of sex predilection, histopathology, salivary deficits, and autoantibodies. äThe Osteopontin Transgenic Mouse is a New Model for Sjögren?s Syndrome(epmc).pdf DeepDyve Pubget Overpricing