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10.1016/j.devcel.2015.01.005 http://scihub22266oqcxt.onion/10.1016/j.devcel.2015.01.005 C4357538!4357538!25684354     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25684354&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Dev+Cell 2015 ; 32 (5): 561-73 Nephropedia Template TP {{tp|p=25684354|t=2015. Mechanical tension drives cell membrane fusion |pdf=|usr=}}{{25684354}} gab.com Text Mechanical tension drives cell membrane fusion JO: Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=25684354 #FOAvip Membrane fusion is an energy-consuming process that requires tight juxtaposition of two lipid bilayers. Little is known about how cells overcome energy barriers to bring their membranes together for fusion. Previously, we have shown that cell-cell fusion is an asymmetric process in which an ?attacking? cell drills finger-like protrusions into the ?receiving? cell to promote cell fusion. Here we show that the receiving cell mounts a Myosin II (MyoII)-mediated mechanosensory response to its invasive fusion partner. MyoII acts as a mechanosensor, which directs its force-induced recruitment to the fusion site, and the mechanosensory response of MyoII is amplified by cell adhesion molecule-initiated chemical signaling. The accumulated MyoII, in turn, increases cortical tension and promotes fusion pore formation. We propose that the protrusive and resisting forces from two fusion partners put the fusogenic synapse under high mechanical tension, which helps to overcome energy barriers for membrane apposition and drives cell membrane fusion. Twit Text FOAVip Mechanical tension drives cell membrane fusion ????Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=25684354 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25684354 #FOAvip English Wikipedia <ref>{{Cite pmid|25684354}}</ref> Mechanical tension drives cell membrane fusion #MMPMID25684354 Kim JH; Ren Y; Ng WP; Li S; Son S; Kee YS; Zhang S; Zhang G; Fletcher DA; Robinson DN; Chen EH Dev Cell 2015[Mar]; 32 (5): 561-73 PMID25684354show ga Membrane fusion is an energy-consuming process that requires tight juxtaposition of two lipid bilayers. Little is known about how cells overcome energy barriers to bring their membranes together for fusion. Previously, we have shown that cell-cell fusion is an asymmetric process in which an ?attacking? cell drills finger-like protrusions into the ?receiving? cell to promote cell fusion. Here we show that the receiving cell mounts a Myosin II (MyoII)-mediated mechanosensory response to its invasive fusion partner. MyoII acts as a mechanosensor, which directs its force-induced recruitment to the fusion site, and the mechanosensory response of MyoII is amplified by cell adhesion molecule-initiated chemical signaling. The accumulated MyoII, in turn, increases cortical tension and promotes fusion pore formation. We propose that the protrusive and resisting forces from two fusion partners put the fusogenic synapse under high mechanical tension, which helps to overcome energy barriers for membrane apposition and drives cell membrane fusion. äMechanical tension drives cell membrane fusion (epmc).pdf DeepDyve Pubget Overpricing