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10.4049/jimmunol.1400326 http://scihub22266oqcxt.onion/10.4049/jimmunol.1400326 C4355390!4355390!25662996     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2015 ; 194 (6): 2587-95 Nephropedia Template TP {{tp|p=25662996|t=2015. Quantitative reduction of the T cell receptor adapter protein SLP-76 unbalances immunity and immune regulation |pdf=|usr=}}{{25662996}} gab.com Text Quantitative reduction of the T cell receptor adapter protein SLP-76 unbalances immunity and immune regulation JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25662996 #FOAvip Gene variants that disrupt T cell receptor signaling can cause severe immune deficiency, yet less disruptive variants are sometimes associated with immune pathology. Null mutations of the gene encoding the scaffold protein SLP-76, for example, cause an arrest of T cell positive selection, while a synthetic membrane-targeted allele allows limited positive selection but is associated with proinflammatory cytokine production and autoantibodies. Whether these and other enigmatic outcomes are due to a biochemical uncoupling of tolerogenic signaling, or simply a quantitative reduction of protein activity, remains to be determined. We describe here a splice variant of Lcp2 that reduced the amount of wild-type SLP-76 protein by ~90%, disrupting immunogenic and tolerogenic pathways to different degrees. Mutant mice produced excessive amounts of proinflammatory cytokines, autoantibodies and IgE, revealing that simple quantitative reductions of SLP-76 were sufficient to trigger immune dysregulation. This allele reveals a dose-sensitive threshold for SLP-76 in the balance of immunity and immune dysregulation: a common disturbance of atypical clinical immune deficiencies. Twit Text FOAVip Quantitative reduction of the T cell receptor adapter protein SLP-76 unbalances immunity and immune regulation ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25662996 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25662996 #FOAvip English Wikipedia <ref>{{Cite pmid|25662996}}</ref> Quantitative reduction of the T cell receptor adapter protein SLP-76 unbalances immunity and immune regulation #MMPMID25662996 Siggs OM; Miosge LA; Daley SR; Asquith K; Foster PS; Liston A; Goodnow CC J Immunol 2015[Mar]; 194 (6): 2587-95 PMID25662996show ga Gene variants that disrupt T cell receptor signaling can cause severe immune deficiency, yet less disruptive variants are sometimes associated with immune pathology. Null mutations of the gene encoding the scaffold protein SLP-76, for example, cause an arrest of T cell positive selection, while a synthetic membrane-targeted allele allows limited positive selection but is associated with proinflammatory cytokine production and autoantibodies. Whether these and other enigmatic outcomes are due to a biochemical uncoupling of tolerogenic signaling, or simply a quantitative reduction of protein activity, remains to be determined. We describe here a splice variant of Lcp2 that reduced the amount of wild-type SLP-76 protein by ~90%, disrupting immunogenic and tolerogenic pathways to different degrees. Mutant mice produced excessive amounts of proinflammatory cytokines, autoantibodies and IgE, revealing that simple quantitative reductions of SLP-76 were sufficient to trigger immune dysregulation. This allele reveals a dose-sensitive threshold for SLP-76 in the balance of immunity and immune dysregulation: a common disturbance of atypical clinical immune deficiencies. äQuantitative reduction of the T cell receptor adapter protein SLP-76 u(epmc).pdf DeepDyve Pubget Overpricing