Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.4049/jimmunol.1402211 http://scihub22266oqcxt.onion/10.4049/jimmunol.1402211 C4355282!4355282!25694609     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2015 ; 194 (6): 2878-87 Nephropedia Template TP {{tp|p=25694609|t=2015. FOXO1 Mediates RANKL Induced Osteoclast Formation and Activity |pdf=|usr=}}{{25694609}} gab.com Text FOXO1 Mediates RANKL Induced Osteoclast Formation and Activity JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25694609 #FOAvip We have previously shown that the transcription factor FOXO1 is elevated in conditions with high levels of bone resorption. To investigate the role of FOXO1 in the formation of osteoclasts we examined mice with lineage specific deletion of FOXO1 in osteoclast precursors and by knockdown of FOXO1 with siRNA. The receptor activator of NF-kappa B ligand (RANKL), a principal bone resorbing factor, induced FOXO1 expression and nuclear localization two days after stimulation in bone marrow macrophages (BMMs) and RAW264.7 osteoclast precursors. RANKL- induced osteoclast formation and osteoclast activity was reduced in half in vivo and in vitro with lineage specific FOXO1 deletion (LyzM.Cre+FOXO1L/L) compared to matched controls (LyzM.Cre?FOXO1L/L). Similar results were obtained by knockdown of FOXO1 in RAW264.7 cells. Moreover, FOXO1-mediated osteoclast formation was linked to regulation of NFATc1 nuclear localization and expression as well as a number of downstream factors including dendritic cell-specific transmembrane protein (DC-STAMP), ATP6vod2, cathepsin K and integrin ?? Lastly, FOXO1 deletion reduced M-CSF induced RANK expression and migration of osteoclast precursors. Studies presented here provide the evidence that FOXO1 plays a direct role in osteoclast formation by mediating the effect of RANKL on NFATc1 and several downstream effectors. This is likely to be significant since FOXO1 and RANKL are elevated in osteolytic conditions. Twit Text FOAVip FOXO1 Mediates RANKL Induced Osteoclast Formation and Activity ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25694609 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25694609 #FOAvip English Wikipedia <ref>{{Cite pmid|25694609}}</ref> FOXO1 Mediates RANKL Induced Osteoclast Formation and Activity #MMPMID25694609 Wang Y; Dong G; Jeon HH; Elazizi M; La LB; Hameedaldeen A; Xiao E; Tian C; Alsadun S; Choi Y; Graves DT J Immunol 2015[Mar]; 194 (6): 2878-87 PMID25694609show ga We have previously shown that the transcription factor FOXO1 is elevated in conditions with high levels of bone resorption. To investigate the role of FOXO1 in the formation of osteoclasts we examined mice with lineage specific deletion of FOXO1 in osteoclast precursors and by knockdown of FOXO1 with siRNA. The receptor activator of NF-kappa B ligand (RANKL), a principal bone resorbing factor, induced FOXO1 expression and nuclear localization two days after stimulation in bone marrow macrophages (BMMs) and RAW264.7 osteoclast precursors. RANKL- induced osteoclast formation and osteoclast activity was reduced in half in vivo and in vitro with lineage specific FOXO1 deletion (LyzM.Cre+FOXO1L/L) compared to matched controls (LyzM.Cre?FOXO1L/L). Similar results were obtained by knockdown of FOXO1 in RAW264.7 cells. Moreover, FOXO1-mediated osteoclast formation was linked to regulation of NFATc1 nuclear localization and expression as well as a number of downstream factors including dendritic cell-specific transmembrane protein (DC-STAMP), ATP6vod2, cathepsin K and integrin ?? Lastly, FOXO1 deletion reduced M-CSF induced RANK expression and migration of osteoclast precursors. Studies presented here provide the evidence that FOXO1 plays a direct role in osteoclast formation by mediating the effect of RANKL on NFATc1 and several downstream effectors. This is likely to be significant since FOXO1 and RANKL are elevated in osteolytic conditions. äFOXO1 Mediates RANKL Induced Osteoclast Formation and Activity (epmc).pdf DeepDyve Pubget Overpricing