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10.1101/cshperspect.a019406 http://scihub22266oqcxt.onion/10.1101/cshperspect.a019406 C4355265!4355265!25731764     free     free     free       Cold+Spring+Harb+Perspect+Biol 2015 ; 7 (3): ä Nephropedia Template TP {{tp|p=25731764|t=2015. Dosage Compensation in Mammals |pdf=|usr=}}{{25731764}} gab.com Text Dosage Compensation in Mammals JO: Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=25731764 #FOAvip Many organisms show major chromosomal differences between sexes. In mammals, females have two copies of a large, gene-rich chromosome, the X, whereas males have one X and a small, gene-poor Y. The imbalance in expression of several hundred genes is lethal if not dealt with by dosage compensation. The male?female difference is addressed by silencing of genes on one female X early in development. However, both males and females now have only one active X chromosome. This is compensated by twofold up-regulation of genes on the active X. This complex system continues to provide important insights into mechanisms of epigenetic regulation. Twit Text FOAVip Dosage Compensation in Mammals ????Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=25731764 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25731764 #FOAvip English Wikipedia <ref>{{Cite pmid|25731764}}</ref> Dosage Compensation in Mammals #MMPMID25731764 Brockdorff N; Turner BM Cold Spring Harb Perspect Biol 2015[Mar]; 7 (3): ä PMID25731764show ga Many organisms show major chromosomal differences between sexes. In mammals, females have two copies of a large, gene-rich chromosome, the X, whereas males have one X and a small, gene-poor Y. The imbalance in expression of several hundred genes is lethal if not dealt with by dosage compensation. The male?female difference is addressed by silencing of genes on one female X early in development. However, both males and females now have only one active X chromosome. This is compensated by twofold up-regulation of genes on the active X. This complex system continues to provide important insights into mechanisms of epigenetic regulation. äDosage Compensation in Mammals (epmc).pdf DeepDyve Pubget Overpricing