Sirtuin inhibitor sirtinol is an intracellular iron chelator #MMPMID25715179
Gautam R; Akam EA; Astashkin AV; Loughrey JJ; Tomat E
Chem Commun (Camb) 2015[Mar]; 51 (24): 5104-7 PMID25715179show ga
Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda.