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10.1039/c5cc00829h

http://scihub22266oqcxt.onion/10.1039/c5cc00829h
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C4355247!4355247!25715179
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suck abstract from ncbi

pmid25715179      Chem+Commun+(Camb) 2015 ; 51 (24): 5104-7
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  • Sirtuin inhibitor sirtinol is an intracellular iron chelator #MMPMID25715179
  • Gautam R; Akam EA; Astashkin AV; Loughrey JJ; Tomat E
  • Chem Commun (Camb) 2015[Mar]; 51 (24): 5104-7 PMID25715179show ga
  • Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda.
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