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10.1016/j.jaci.2014.09.015 http://scihub22266oqcxt.onion/10.1016/j.jaci.2014.09.015 C4355221!4355221!25441291     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Allergy+Clin+Immunol 2015 ; 135 (3): 781-791.e3 Nephropedia Template TP {{tp|p=25441291|t=2015. TSLP Signaling in CD4+ T cells is Required for Th2 Memory |pdf=|usr=}}{{25441291}} gab.com Text TSLP Signaling in CD4+ T cells is Required for Th2 Memory JO: J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25441291 #FOAvip Background: Thymic stromal lymphopoietin (TSLP) is a key factor in the development of allergic asthma. Th2 memory cells gradually increase in allergic patients with the progression of disease and persist in the lungs during remission although the mechanism is not clear. Objective: To define the role of TSLP in Th2 memory generation and maintenance in vivo. Methods: Adoptive transfer of wild type (WT) and TSLP receptor (TSLPR)-deficient ovalbumin (OVA)-specific CD4+ T cells before Th2 sensitization was used to define T cell specific TSLP effects. Atopic dermatitis and elevated serum TSLP concentration was induced by topical application of the vitamin D3 analog MC903. Memory cells in peripheral blood were monitored weekly with flow cytometry. Memory recall was tested following intranasal OVA challenge. Results: TSLP signaling in CD4+ T cells is required for the generation/maintenance of memory cells following in vivo priming. TSLPR-deficient CD4+ T cells have no defects in proliferation but fail to survive one week after sensitization, and elevated TSLP expression during sensitization significantly increased the frequency of memory cells. Although in vitro differentiated TSLPR-deficient Th2 cells develop into memory cells with equal efficiency to wild type cells, the recall response to airway antigen challenge is impaired. Moreover, after antigen challenge of mice with established Th2 memory, TSLP signaling in CD4+ T cells significantly affects memory cell generation/maintenance from secondary effector cells. Conclusion: TSLP signaling in CD4+ T cells is required for not only Th2 memory formation in vivo, but also the recall response of the memory cells to local antigen challenge. Twit Text FOAVip TSLP Signaling in CD4+ T cells is Required for Th2 Memory ????J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25441291 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25441291 #FOAvip English Wikipedia <ref>{{Cite pmid|25441291}}</ref> TSLP Signaling in CD4+ T cells is Required for Th2 Memory #MMPMID25441291 Wang Q; Du J; Zhu J; Yang X; Zhou B J Allergy Clin Immunol 2015[Mar]; 135 (3): 781-791.e3 PMID25441291show ga Background: Thymic stromal lymphopoietin (TSLP) is a key factor in the development of allergic asthma. Th2 memory cells gradually increase in allergic patients with the progression of disease and persist in the lungs during remission although the mechanism is not clear. Objective: To define the role of TSLP in Th2 memory generation and maintenance in vivo. Methods: Adoptive transfer of wild type (WT) and TSLP receptor (TSLPR)-deficient ovalbumin (OVA)-specific CD4+ T cells before Th2 sensitization was used to define T cell specific TSLP effects. Atopic dermatitis and elevated serum TSLP concentration was induced by topical application of the vitamin D3 analog MC903. Memory cells in peripheral blood were monitored weekly with flow cytometry. Memory recall was tested following intranasal OVA challenge. Results: TSLP signaling in CD4+ T cells is required for the generation/maintenance of memory cells following in vivo priming. TSLPR-deficient CD4+ T cells have no defects in proliferation but fail to survive one week after sensitization, and elevated TSLP expression during sensitization significantly increased the frequency of memory cells. Although in vitro differentiated TSLPR-deficient Th2 cells develop into memory cells with equal efficiency to wild type cells, the recall response to airway antigen challenge is impaired. Moreover, after antigen challenge of mice with established Th2 memory, TSLP signaling in CD4+ T cells significantly affects memory cell generation/maintenance from secondary effector cells. Conclusion: TSLP signaling in CD4+ T cells is required for not only Th2 memory formation in vivo, but also the recall response of the memory cells to local antigen challenge. äTSLP Signaling in CD4+ T cells is Required for Th2 Memory (epmc).pdf DeepDyve Pubget Overpricing