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10.1016/j.ymben.2015.01.002 http://scihub22266oqcxt.onion/10.1016/j.ymben.2015.01.002 C4355220!4355220!25596510     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Metab+Eng 2015 ; 28 (ä): 159-68 Nephropedia Template TP {{tp|p=25596510|t=2015. Metabolic transistor strategy for controlling electron transfer chain activity in Escherichia coli |pdf=|usr=}}{{25596510}} gab.com Text Metabolic transistor strategy for controlling electron transfer chain activity in Escherichia coli JO: Metab Eng http://www.kidney.de/pget.php?&tw=1&pmid=25596510 #FOAvip A novel strategy to finely control a large metabolic flux by using a ?metabolic transistor? approach was established. In this approach a small change in the level or availability of an essential component for the process is controlled by adding a competitive reaction that affects a precursor or an intermediate in its biosynthetic pathway. The change of the basal level of the essential component, considered as a base current in a transistor, has a large effect on the flux through the major pathway. In this way, the fine-tuning of a large flux can be accomplished. The ?metabolic transistor? strategy was applied to controlling electron transfer chain function by manipulation of the quinone synthesis pathway in Escherichia coli. The achievement of a theoretical yield of lactate production under aerobic conditions via this strategy upon manipulation of the biosynthetic pathway of the key participant, ubiquinone-8 (Q8), in an E. coli strain provides an in vivo, genetically tunable means to control the activity of the electron transfer chain and manipulate the production of reduced products while limiting consumption of oxygen to a defined amount. Twit Text FOAVip Metabolic transistor strategy for controlling electron transfer chain activity in Escherichia coli ????Metab Eng http://www.kidney.de/pget.php?&tw=1&pmid=25596510 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25596510 #FOAvip English Wikipedia <ref>{{Cite pmid|25596510}}</ref> Metabolic transistor strategy for controlling electron transfer chain activity in Escherichia coli #MMPMID25596510 Wu H; Tuli L; Bennett GN; San KY Metab Eng 2015[Mar]; 28 (ä): 159-68 PMID25596510show ga A novel strategy to finely control a large metabolic flux by using a ?metabolic transistor? approach was established. In this approach a small change in the level or availability of an essential component for the process is controlled by adding a competitive reaction that affects a precursor or an intermediate in its biosynthetic pathway. The change of the basal level of the essential component, considered as a base current in a transistor, has a large effect on the flux through the major pathway. In this way, the fine-tuning of a large flux can be accomplished. The ?metabolic transistor? strategy was applied to controlling electron transfer chain function by manipulation of the quinone synthesis pathway in Escherichia coli. The achievement of a theoretical yield of lactate production under aerobic conditions via this strategy upon manipulation of the biosynthetic pathway of the key participant, ubiquinone-8 (Q8), in an E. coli strain provides an in vivo, genetically tunable means to control the activity of the electron transfer chain and manipulate the production of reduced products while limiting consumption of oxygen to a defined amount. äMetabolic transistor strategy for controlling electron transfer chain (epmc).pdf DeepDyve Pubget Overpricing