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10.1016/j.bone.2015.01.001 http://scihub22266oqcxt.onion/10.1016/j.bone.2015.01.001 C4355031!4355031!25585248     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bone 2015 ; 74 (ä): 48-57 Nephropedia Template TP {{tp|p=25585248|t=2015. Prevention of glucocorticoid induced bone changes with beta-ecdysone |pdf=|usr=}}{{25585248}} gab.com Text Prevention of glucocorticoid induced bone changes with beta-ecdysone JO: Bone http://www.kidney.de/pget.php?&tw=1&pmid=25585248 #FOAvip Beta-ecdysone (?Ecd) is a phytoecdysteroid found in the dry roots and seeds of the asteraceae and achyranthes plants, and is reported to increase osteogenesis in vitro. Since glucocorticoid (GCs) excess is associated with a decrease in bone formation, the purpose of this study was to determine if treatment with ?Ecd could prevent GC-induced osteoporosis. Two-month-old male Swiss-Webster mice (n=8-10/group) were randomized to either placebo or slow release prednisolone pellets (3.3mg/kg/d) and treated with vehicle control or ?Ecd (0.5mg/kg/d) for 21 days. GC treatment inhibited age-dependent trabecular gain and cortical bone expansion and this was accompanied by a 30-50% lower bone formation rate (BFR) at both the endosteal and periosteal surfaces. Mice treated with only ?Ecd significantly increased bone formation on endosteal and periosteal bone surfaces, and increased cortical bone mass were their controls to compare to GC alone. Concurrent treatment of ?Ecd and GC completely prevented the GC-induced reduction in BFR, trabecular bone volume and partially prevented cortical bone loss. In vitro studies determined that ?Ecd prevented the GC increase in autophagy of the bone marrow stromal cells as well as in whole bone. In summary, ?Ecd prevented GC induced changes in bone formation, bone cell viability and bone mass. Additional studies are warranted of ?Ecd for the treatment of GC induced bone loss. Twit Text FOAVip Prevention of glucocorticoid induced bone changes with beta-ecdysone ????Bone http://www.kidney.de/pget.php?&tw=1&pmid=25585248 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25585248 #FOAvip English Wikipedia <ref>{{Cite pmid|25585248}}</ref> Prevention of glucocorticoid induced bone changes with beta-ecdysone #MMPMID25585248 Dai W; Jiang L; Lay YAE; Chen H; Jin G; Zhang H; Kot A; Ritchie RO; Lane NE; Yao W Bone 2015[May]; 74 (ä): 48-57 PMID25585248show ga Beta-ecdysone (?Ecd) is a phytoecdysteroid found in the dry roots and seeds of the asteraceae and achyranthes plants, and is reported to increase osteogenesis in vitro. Since glucocorticoid (GCs) excess is associated with a decrease in bone formation, the purpose of this study was to determine if treatment with ?Ecd could prevent GC-induced osteoporosis. Two-month-old male Swiss-Webster mice (n=8-10/group) were randomized to either placebo or slow release prednisolone pellets (3.3mg/kg/d) and treated with vehicle control or ?Ecd (0.5mg/kg/d) for 21 days. GC treatment inhibited age-dependent trabecular gain and cortical bone expansion and this was accompanied by a 30-50% lower bone formation rate (BFR) at both the endosteal and periosteal surfaces. Mice treated with only ?Ecd significantly increased bone formation on endosteal and periosteal bone surfaces, and increased cortical bone mass were their controls to compare to GC alone. Concurrent treatment of ?Ecd and GC completely prevented the GC-induced reduction in BFR, trabecular bone volume and partially prevented cortical bone loss. In vitro studies determined that ?Ecd prevented the GC increase in autophagy of the bone marrow stromal cells as well as in whole bone. In summary, ?Ecd prevented GC induced changes in bone formation, bone cell viability and bone mass. Additional studies are warranted of ?Ecd for the treatment of GC induced bone loss. äPrevention of glucocorticoid induced bone changes with beta-ecdysone (epmc).pdf DeepDyve Pubget Overpricing