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2015 ; 44
(ä): 80-87
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Neural activation during response inhibition is associated with adolescents
frequency of risky sex and substance use
#MMPMID25532443
Feldstein Ewing SW
; Houck JM
; Bryan AD
Addict Behav
2015[May]; 44
(ä): 80-87
PMID25532443
show ga
INTRODUCTION: While many have identified the important role of the developing
brain in youth risk behavior, few have examined the relationship between salient
cognitive factors (response inhibition) and different types of real-world
adolescent health risk behaviors such as substance use and risky sex, within the
same sample of youth. METHODS: We therefore sought to examine these relationships
with 95 high-risk youth (ages 14-18; M age = 16.29 years). We examined blood
oxygen level dependent (BOLD) response to an fMRI-based cognitive task designed
to assess response inhibition (Go/NoGo) and past month risk behavior (number of
substance use days; number of unprotected sex days). RESULTS: For this sample of
youth, we found significant negative correlations between past month substance
use and response inhibition within the left inferior frontal gyrus (IFG) and
right insula (uncorrected p < .001; extent threshold ? 10 voxels). In addition,
in the same contrast, we found significant positive correlations between past
month risky sex and activation within the right IFG and left middle occipital
gyrus (uncorrected p < .001; extent threshold ? 10 voxels). CONCLUSIONS: These
results suggest the particular relevance of these regions in this compelling,
albeit slightly different, pattern of response for adolescent risky behaviors.