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10.1039/c4cc10374b

http://scihub22266oqcxt.onion/10.1039/c4cc10374b
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C4352935!4352935!25703347
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suck abstract from ncbi


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pmid25703347      Chem+Commun+(Camb) 2015 ; 51 (23): 4899-901
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  • Enzyme transformation to modulate the ligand-receptor interactions between small molecules #MMPMID25703347
  • Shi J; Du X; Yuan D; Haburcak R; Wu D; Zhou N; Xu B
  • Chem Commun (Camb) 2015[Mar]; 51 (23): 4899-901 PMID25703347show ga
  • Enzymatic transformation is a fundamental process to control ligand-receptor interactions among proteins for signal transduction in cells. Here we report the first example of enzymatic transformation regulated ligand-receptor interactions of small molecules, in which enzymatic reaction changes the stoichiometry of the ligand-receptor binding from 1:1 to 1:2. We also show that this unique integration of enzymatic transformation and ligand-receptor interactions of small molecules is able to affect the fate of cells.
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