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10.1073/pnas.1416655112 http://scihub22266oqcxt.onion/10.1073/pnas.1416655112 C4352827!4352827!25730853     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (9): 2652-7 Nephropedia Template TP {{tp|p=25730853|t=2015. Parameter-free methods distinguish Wnt pathway models and guide design of experiments |pdf=|usr=}}{{25730853}} gab.com Text Parameter-free methods distinguish Wnt pathway models and guide design of experiments JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25730853 #FOAvip The canonical Wnt/?-catenin signaling pathway is important for essential cellular functions and is implicated in many diseases. We introduce a new mathematical model that focuses on ?-catenin degradation and protein shuttling between cellular compartments. We compare our model to others and show that all fit to time-dependent experimental data. To evade this parameter problem, we use algebraic methods and characterize model features that are independent of the choice of parameter values. We find that multiple responses to Wnt are feasible under certain conditions for the new model, but not for the others; moreover, we provide dependencies between species (variables) that inform future experiments and model discrimination. We also highlight the wide applicability of these tools across problems in systems biology. Twit Text FOAVip Parameter-free methods distinguish Wnt pathway models and guide design of experiments ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25730853 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25730853 #FOAvip English Wikipedia <ref>{{Cite pmid|25730853}}</ref> Parameter-free methods distinguish Wnt pathway models and guide design of experiments #MMPMID25730853 MacLean AL; Rosen Z; Byrne HM; Harrington HA Proc Natl Acad Sci U S A 2015[Mar]; 112 (9): 2652-7 PMID25730853show ga The canonical Wnt/?-catenin signaling pathway is important for essential cellular functions and is implicated in many diseases. We introduce a new mathematical model that focuses on ?-catenin degradation and protein shuttling between cellular compartments. We compare our model to others and show that all fit to time-dependent experimental data. To evade this parameter problem, we use algebraic methods and characterize model features that are independent of the choice of parameter values. We find that multiple responses to Wnt are feasible under certain conditions for the new model, but not for the others; moreover, we provide dependencies between species (variables) that inform future experiments and model discrimination. We also highlight the wide applicability of these tools across problems in systems biology. äParameter-free methods distinguish Wnt pathway models and guide design(epmc).pdf DeepDyve Pubget Overpricing