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10.4049/jimmunol.1400968 http://scihub22266oqcxt.onion/10.4049/jimmunol.1400968 C4352551!4352551 !25063868     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25063868 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2014 ; 193 (5 ): 2267-72 Nephropedia Template TP {{tp|p=25063868 |t=2014. IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function |pdf=|usr=}}{{25063868 }} gab.com Text IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25063868 #FOAvip IL-2-inducible T cell kinase (ITK) is a key signaling mediator downstream of TCR, mediating T cell positive selection, as well as innate T cell and CD4(+) Th2/Th17 differentiation. In this article, we show that ITK also negatively tunes IL-2-induced expansion of conventional Foxp3-expressing regulatory T cells (Tregs). In vivo, Treg abundance is inversely correlated with ITK expression, and inducible Treg development is inversely dependent on ITK kinase activity. While Treg development normally requires both hematopoietic and thymic MHC class 2 (MHC2) expression, the absence of ITK allows Treg development with MHC2 expression in either compartment, with preference for selection by thymic MHC2, suggesting a gatekeeper role for ITK in ensuring that only Tregs selected by both thymic and hematopoietic MHC2 survive selection. Although ITK suppresses Treg development and is not required for maintenance of neuropilin-1-positive natural Tregs in the periphery, it is indispensable for Treg functional suppression of naive CD4(+) T cell-induced colitis in Rag(-/-) recipients. ITK thus regulates the development and function of Tregs. Twit Text FOAVip IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25063868 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25063868 #FOAvip English Wikipedia <ref>{{Cite pmid|25063868 }}</ref> IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function #MMPMID25063868 Huang W ; Jeong AR ; Kannan AK ; Huang L ; August A J Immunol 2014[Sep]; 193 (5 ): 2267-72 PMID25063868 show ga IL-2-inducible T cell kinase (ITK) is a key signaling mediator downstream of TCR, mediating T cell positive selection, as well as innate T cell and CD4(+) Th2/Th17 differentiation. In this article, we show that ITK also negatively tunes IL-2-induced expansion of conventional Foxp3-expressing regulatory T cells (Tregs). In vivo, Treg abundance is inversely correlated with ITK expression, and inducible Treg development is inversely dependent on ITK kinase activity. While Treg development normally requires both hematopoietic and thymic MHC class 2 (MHC2) expression, the absence of ITK allows Treg development with MHC2 expression in either compartment, with preference for selection by thymic MHC2, suggesting a gatekeeper role for ITK in ensuring that only Tregs selected by both thymic and hematopoietic MHC2 survive selection. Although ITK suppresses Treg development and is not required for maintenance of neuropilin-1-positive natural Tregs in the periphery, it is indispensable for Treg functional suppression of naive CD4(+) T cell-induced colitis in Rag(-/-) recipients. ITK thus regulates the development and function of Tregs. |*Immune Tolerance [MESH] |Animals [MESH] |Colitis/genetics/*immunology/pathology [MESH] |Forkhead Transcription Factors/genetics/immunology [MESH] |Gene Expression Regulation/genetics/*immunology [MESH] |Histocompatibility Antigens Class II/genetics/*immunology [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Neuropilin-1/genetics/immunology [MESH] |Protein-Tyrosine Kinases/genetics/*immunology [MESH] |T-Lymphocytes, Regulatory/*immunology/pathology [MESH]IL-2-inducible T cell kinase tunes T regulatory cell development and i(epmc).pdf DeepDyve Pubget Overpricing