Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/nnano.2014.274 http://scihub22266oqcxt.onion/10.1038/nnano.2014.274 C4351925!4351925!25420034     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Nanotechnol 2014 ; 9 (12): 1054-62 Nephropedia Template TP {{tp|p=25420034|t=2014. Squalenoyl Adenosine Nanoparticles provide Neuroprotection after Stroke and Spinal Cord Injury |pdf=|usr=}}{{25420034}} gab.com Text Squalenoyl Adenosine Nanoparticles provide Neuroprotection after Stroke and Spinal Cord Injury JO: Nat Nanotechnol http://www.kidney.de/pget.php?&tw=1&pmid=25420034 #FOAvip There is an urgent need to develop new therapeutic approaches for the treatment of severe neurological trauma, such as stroke and spinal cord injuries. However, many drugs with potential neuropharmacological activity, like adenosine, are inefficient upon systemic administration because of their fast metabolisation and rapid clearance from the bloodstream. Here, we show that the conjugation of adenosine to the lipid squalene and the subsequent formation of nanoassemblies allow a prolonged circulation of this nucleoside, to provide neuroprotection in mouse stroke and rat spinal cord injury models. The animals receiving systemic administration of squalenoyl adenosine nanoassemblies showed a significant improvement of their neurologic deficit score in the case of cerebral ischaemia, and an early motor recovery of the hindlimbs in the case of spinal cord injury. Moreover, in vitro and in vivo studies demonstrated that the nanoassemblies were able to extend adenosine circulation and its interaction with the neurovascular unit. This paper shows, for the first time, that a hydrophilic and rapidly metabolised molecule like adenosine may become pharmacologically efficient owing to a single conjugation with the lipid squalene. Twit Text FOAVip Squalenoyl Adenosine Nanoparticles provide Neuroprotection after Stroke and Spinal Cord Injury ????Nat Nanotechnol http://www.kidney.de/pget.php?&tw=1&pmid=25420034 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25420034 #FOAvip English Wikipedia <ref>{{Cite pmid|25420034}}</ref> Squalenoyl Adenosine Nanoparticles provide Neuroprotection after Stroke and Spinal Cord Injury #MMPMID25420034 Gaudin A; Yemisci M; Eroglu H; Lepêtre-Mouelhi S; Turkoglu OF; Dönmez-Demir B; Caban S; Fevzi Sargon M; Garcia-Argote S; Pieters G; Loreau O; Rousseau B; Tagit O; Hildebrandt N; Le Dantec Y; Mougin J; Valetti S; Chacun H; Nicolas V; Desmaële D; Andrieux K; Capan Y; Dalkara T; Couvreur P Nat Nanotechnol 2014[]; 9 (12): 1054-62 PMID25420034show ga There is an urgent need to develop new therapeutic approaches for the treatment of severe neurological trauma, such as stroke and spinal cord injuries. However, many drugs with potential neuropharmacological activity, like adenosine, are inefficient upon systemic administration because of their fast metabolisation and rapid clearance from the bloodstream. Here, we show that the conjugation of adenosine to the lipid squalene and the subsequent formation of nanoassemblies allow a prolonged circulation of this nucleoside, to provide neuroprotection in mouse stroke and rat spinal cord injury models. The animals receiving systemic administration of squalenoyl adenosine nanoassemblies showed a significant improvement of their neurologic deficit score in the case of cerebral ischaemia, and an early motor recovery of the hindlimbs in the case of spinal cord injury. Moreover, in vitro and in vivo studies demonstrated that the nanoassemblies were able to extend adenosine circulation and its interaction with the neurovascular unit. This paper shows, for the first time, that a hydrophilic and rapidly metabolised molecule like adenosine may become pharmacologically efficient owing to a single conjugation with the lipid squalene. äSqualenoyl Adenosine Nanoparticles provide Neuroprotection after Strok(epmc).pdf DeepDyve Pubget Overpricing