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10.1111/iep.12079 http://scihub22266oqcxt.onion/10.1111/iep.12079 C4351853!4351853!24761792     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Exp+Pathol 2014 ; 95 (3): 158-80 Nephropedia Template TP {{tp|p=24761792|t=2014. Illustrating the interplay between the extracellular matrix and microRNAs |pdf=|usr=}}{{24761792}} gab.com Text Illustrating the interplay between the extracellular matrix and microRNAs JO: Int J Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=24761792 #FOAvip The discovery of cell surface receptors that bind to extracellular matrix (ECM) components marked a new era in biological research. Since then there has been an increasing appreciation of the importance of studying cells in the context of their extracellular environment. Cell behaviour is profoundly affected by the ECM, whose synthesis and turnover must be finely balanced in order to maintain normal function and prevent disease. In the last decade, microRNAs (miRNAs) have emerged as key regulators of ECM gene expression. As new technologies for the identification and validation of miRNA targets continue to be developed, a growing body of data supporting the role of miRNAs in regulating the ECM biology has arisen from a variety of cell and animal models along with clinical studies. However, more recent findings suggest an intriguing interplay between the ECM and miRNAs: not only can miRNAs control the composition of the ECM, but also the ECM can affect the expression of specific miRNAs. Here we discuss how miRNAs contribute to the synthesis, maintenance and remodelling of the ECM during development and disease. Furthermore, we bring to light evidence that points to a role for the ECM in regulating miRNA expression and function. Twit Text FOAVip Illustrating the interplay between the extracellular matrix and microRNAs ????Int J Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=24761792 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24761792 #FOAvip English Wikipedia <ref>{{Cite pmid|24761792}}</ref> Illustrating the interplay between the extracellular matrix and microRNAs #MMPMID24761792 Piccinini AM; Midwood KS Int J Exp Pathol 2014[Jun]; 95 (3): 158-80 PMID24761792show ga The discovery of cell surface receptors that bind to extracellular matrix (ECM) components marked a new era in biological research. Since then there has been an increasing appreciation of the importance of studying cells in the context of their extracellular environment. Cell behaviour is profoundly affected by the ECM, whose synthesis and turnover must be finely balanced in order to maintain normal function and prevent disease. In the last decade, microRNAs (miRNAs) have emerged as key regulators of ECM gene expression. As new technologies for the identification and validation of miRNA targets continue to be developed, a growing body of data supporting the role of miRNAs in regulating the ECM biology has arisen from a variety of cell and animal models along with clinical studies. However, more recent findings suggest an intriguing interplay between the ECM and miRNAs: not only can miRNAs control the composition of the ECM, but also the ECM can affect the expression of specific miRNAs. Here we discuss how miRNAs contribute to the synthesis, maintenance and remodelling of the ECM during development and disease. Furthermore, we bring to light evidence that points to a role for the ECM in regulating miRNA expression and function. äIllustrating the interplay between the extracellular matrix and microR(epmc).pdf DeepDyve Pubget Overpricing