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10.1182/blood-2014-04-568949

http://scihub22266oqcxt.onion/10.1182/blood-2014-04-568949
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C4351504!4351504!25593337
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suck abstract from ncbi


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pmid25593337      Blood 2015 ; 125 (10): 1562-5
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  • Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism #MMPMID25593337
  • Liu X; Zheng H; Yu WM; Cooper TM; Bunting KD; Qu CK
  • Blood 2015[Mar]; 125 (10): 1562-5 PMID25593337show ga
  • Treatment with alexidine dihydrochloride, a Ptpmt1 inhibitor, reprograms cellular metabolism and preserves long-term stem cells ex vivo.Inhibition of mitochondrial metabolism by metformin also decreases differentiation and helps maintain stem cells in culture.
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