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10.1016/j.neuron.2015.02.007 http://scihub22266oqcxt.onion/10.1016/j.neuron.2015.02.007 C4351476!4351476 !25741731     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25741731 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25741731 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Neuron 2015 ; 85 (5 ): 1117-31 Nephropedia Template TP {{tp|p=25741731 |t=2015. Supply-demand mismatch transients in susceptible peri-infarct hot zones explain the origins of spreading injury depolarizations |pdf=|usr=}}{{25741731 }} gab.com Text Supply-demand mismatch transients in susceptible peri-infarct hot zones explain the origins of spreading injury depolarizations JO: Neuron http://www.kidney.de/pget.php?&tw=1&pmid=25741731 #FOAvip Peri-infarct depolarizations (PIDs) are seemingly spontaneous spreading depression-like waves that negatively impact tissue outcome in both experimental and human stroke. Factors triggering PIDs are unknown. Here, we show that somatosensory activation of peri-infarct cortex triggers PIDs when the activated cortex is within a critical range of ischemia. We show that the mechanism involves increased oxygen utilization within the activated cortex, worsening the supply-demand mismatch. We support the concept by clinical data showing that mismatch predisposes stroke patients to PIDs as well. Conversely, transient worsening of mismatch by episodic hypoxemia or hypotension also reproducibly triggers PIDs. Therefore, PIDs are triggered upon supply-demand mismatch transients in metastable peri-infarct hot zones due to increased demand or reduced supply. Based on the data, we propose that minimizing sensory stimulation and hypoxic or hypotensive transients in stroke and brain injury would reduce PID incidence and their adverse impact on outcome. Twit Text FOAVip Supply-demand mismatch transients in susceptible peri-infarct hot zones explain the origins of spreading injury depolarizations ????Neuron http://www.kidney.de/pget.php?&tw=1&pmid=25741731 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25741731 #FOAvip English Wikipedia <ref>{{Cite pmid|25741731 }}</ref> Supply-demand mismatch transients in susceptible peri-infarct hot zones explain the origins of spreading injury depolarizations #MMPMID25741731 von Bornstädt D ; Houben T ; Seidel JL ; Zheng Y ; Dilekoz E ; Qin T ; Sandow N ; Kura S ; Eikermann-Haerter K ; Endres M ; Boas DA ; Moskowitz MA ; Lo EH ; Dreier JP ; Woitzik J ; Sakad?i? S ; Ayata C Neuron 2015[Mar]; 85 (5 ): 1117-31 PMID25741731 show ga Peri-infarct depolarizations (PIDs) are seemingly spontaneous spreading depression-like waves that negatively impact tissue outcome in both experimental and human stroke. Factors triggering PIDs are unknown. Here, we show that somatosensory activation of peri-infarct cortex triggers PIDs when the activated cortex is within a critical range of ischemia. We show that the mechanism involves increased oxygen utilization within the activated cortex, worsening the supply-demand mismatch. We support the concept by clinical data showing that mismatch predisposes stroke patients to PIDs as well. Conversely, transient worsening of mismatch by episodic hypoxemia or hypotension also reproducibly triggers PIDs. Therefore, PIDs are triggered upon supply-demand mismatch transients in metastable peri-infarct hot zones due to increased demand or reduced supply. Based on the data, we propose that minimizing sensory stimulation and hypoxic or hypotensive transients in stroke and brain injury would reduce PID incidence and their adverse impact on outcome. |Adult [MESH] |Aged [MESH] |Animals [MESH] |Cerebral Infarction/*metabolism/pathology [MESH] |Cortical Spreading Depression/*physiology [MESH] |Female [MESH] |Humans [MESH] |Infarction, Middle Cerebral Artery/*metabolism/pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Middle Aged [MESH]Supply-demand mismatch transients in susceptible peri-infarct hot zone(epmc).pdf DeepDyve Pubget Overpricing