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10.1038/mt.2014.217 http://scihub22266oqcxt.onion/10.1038/mt.2014.217 C4351453!4351453 !25373521     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25373521 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Ther 2015 ; 23 (3 ): 549-60 Nephropedia Template TP {{tp|p=25373521 |t=2015. Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using stanniocalcin-1 |pdf=|usr=}}{{25373521 }} gab.com Text Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using stanniocalcin-1 JO: Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=25373521 #FOAvip Current hypotheses suggest that aberrant wound healing has a critical role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). In these hypotheses, continuous TGF-?1 secretion by alveolar epithelial cells (AECs) in abnormal wound healing has a critical role in promoting fibroblast differentiation into myofibroblasts. Mesenchymal stem cells (MSCs) home to the injury site and reduce fibrosis by secreting multifunctional antifibrotic humoral factors in IPF. In this study, we show that MSCs can correct the inadequate-communication between epithelial and mesenchymal cells through STC1 (Stanniocalcin-1) secretion in a bleomycin-induced IPF model. Inhalation of recombinant STC1 shows the same effects as the injection of MSCs. Using STC1 plasmid, it was possible to enhance the ability of MSCs to ameliorate the fibrosis. MSCs secrete large amounts of STC1 in response to TGF-?1 in comparison to AECs and fibroblasts. The antifibrotic effects of STC1 include reducing oxidative stress, endoplasmic reticulum (ER) stress, and TGF-?1 production in AECs. The STC1 effects can be controlled by blocking uncoupling protein 2 (UCP2) and the secretion is affected by the PI3/AKT/mTORC1 inhibitors. Our findings suggest that STC1 tends to correct the inappropriate epithelial-mesenchymal relationships and that STC1 plasmid transfected to MSCs or STC1 inhalation could become promising treatments for IPF. Twit Text FOAVip Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using stanniocalcin-1 ????Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=25373521 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25373521 #FOAvip English Wikipedia <ref>{{Cite pmid|25373521 }}</ref> Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using stanniocalcin-1 #MMPMID25373521 Ono M ; Ohkouchi S ; Kanehira M ; Tode N ; Kobayashi M ; Ebina M ; Nukiwa T ; Irokawa T ; Ogawa H ; Akaike T ; Okada Y ; Kurosawa H ; Kikuchi T ; Ichinose M Mol Ther 2015[Mar]; 23 (3 ): 549-60 PMID25373521 show ga Current hypotheses suggest that aberrant wound healing has a critical role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). In these hypotheses, continuous TGF-?1 secretion by alveolar epithelial cells (AECs) in abnormal wound healing has a critical role in promoting fibroblast differentiation into myofibroblasts. Mesenchymal stem cells (MSCs) home to the injury site and reduce fibrosis by secreting multifunctional antifibrotic humoral factors in IPF. In this study, we show that MSCs can correct the inadequate-communication between epithelial and mesenchymal cells through STC1 (Stanniocalcin-1) secretion in a bleomycin-induced IPF model. Inhalation of recombinant STC1 shows the same effects as the injection of MSCs. Using STC1 plasmid, it was possible to enhance the ability of MSCs to ameliorate the fibrosis. MSCs secrete large amounts of STC1 in response to TGF-?1 in comparison to AECs and fibroblasts. The antifibrotic effects of STC1 include reducing oxidative stress, endoplasmic reticulum (ER) stress, and TGF-?1 production in AECs. The STC1 effects can be controlled by blocking uncoupling protein 2 (UCP2) and the secretion is affected by the PI3/AKT/mTORC1 inhibitors. Our findings suggest that STC1 tends to correct the inappropriate epithelial-mesenchymal relationships and that STC1 plasmid transfected to MSCs or STC1 inhalation could become promising treatments for IPF. |Animals [MESH] |Bleomycin [MESH] |Cell Communication [MESH] |Cytomegalovirus/genetics [MESH] |Endoplasmic Reticulum Stress/genetics [MESH] |Epithelial Cells/*metabolism/pathology [MESH] |Female [MESH] |Fibroblasts/*metabolism/pathology [MESH] |Gene Expression Regulation [MESH] |Genetic Vectors [MESH] |Glycoproteins/genetics/*metabolism [MESH] |Humans [MESH] |Idiopathic Pulmonary Fibrosis/chemically induced/*genetics/metabolism/pathology [MESH] |Ion Channels/genetics/metabolism [MESH] |Mesenchymal Stem Cells/*metabolism/pathology [MESH] |Mice, Inbred C57BL [MESH] |Mitochondrial Proteins/genetics/metabolism [MESH] |Oxidative Stress [MESH] |Plasmids/chemistry/metabolism [MESH] |Pulmonary Alveoli/*metabolism/pathology [MESH] |Signal Transduction [MESH] |Transfection [MESH] |Transforming Growth Factor beta1/genetics/metabolism [MESH]Mesenchymal stem cells correct inappropriate epithelial-mesenchyme rel(epmc).pdf DeepDyve Pubget Overpricing