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10.1007/s11606-014-3115-3 http://scihub22266oqcxt.onion/10.1007/s11606-014-3115-3 C4351273!4351273!25575908     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Gen+Intern+Med 2015 ; 30 (3): 348-58 Nephropedia Template TP {{tp|p=25575908|t=2015. Do Statins Impair Cognition? A Systematic Review and Meta-Analysis of Randomized Controlled Trials |pdf=|usr=}}{{25575908}} gab.com Text Do Statins Impair Cognition A Systematic Review and Meta-Analysis of Randomized Controlled Trials JO: J Gen Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=25575908 #FOAvip BACKGROUND: In 2012, the United States Food and Drug Administration (FDA) issued a warning regarding potential adverse effects of HMG-CoA reductase inhibitors (statins) on cognition, based on the Adverse Events Reporting System and a review of the medical literature. We aimed to synthesize randomized clinical trial (RCTs) evidence on the association between statin therapy and cognitive outcomes. METHODS: We searched MEDLINE, EMBASE, and Cochrane CENTRAL through December 2012, and reviewed published systematic reviews of statin treatment. We sought RCTs that compared statin treatment versus placebo or standard care, and reported at least one cognitive outcome (frequency of adverse cognitive events or measurements using standard neuropsychological cognitive test scores). Studies reporting sufficient information to calculate effect sizes were included in meta-analyses. Standardized and unstandardized mean differences were calculated for continuous outcomes for global cognition and for pre-specified cognitive domains. The main outcome was change in cognition measured by neuropsychological tests; an outcome of secondary interest was the frequency of adverse cognitive events observed during follow-up. RESULTS: We identified 25 RCTs (all placebo-controlled) reporting cognitive outcomes in 46,836 subjects, of which 23 RCTs reported cognitive test results in 29,012 participants. Adverse cognitive outcomes attributable to statins were rarely reported in trials involving cognitively normal or impaired subjects. Furthermore, meta-analysis of cognitive test data (14 studies; 27,643 participants) failed to show significant adverse effects of statins on all tests of cognition in either cognitively normal subjects (standardized mean difference 0.01, 95 % confidence interval, CI, ?0.01 to 0.03, p?=?0.42) or Alzheimer?s disease subjects (standardized mean difference ?0.05, 95 % CI ?0.19 to 0.10, p?=?0.38). CONCLUSIONS: Statin therapy was not associated with cognitive impairment in RCTs. These results raise questions regarding the continued merit of the FDA warning about potential adverse effects of statins on cognition. Electronic supplementary material: The online version of this article (doi:10.1007/s11606-014-3115-3) contains supplementary material, which is available to authorized users. Twit Text FOAVip Do Statins Impair Cognition A Systematic Review and Meta-Analysis of Randomized Controlled Trials ????J Gen Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=25575908 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25575908 #FOAvip English Wikipedia <ref>{{Cite pmid|25575908}}</ref> Do Statins Impair Cognition? A Systematic Review and Meta-Analysis of Randomized Controlled Trials #MMPMID25575908 Ott BR; Daiello LA; Dahabreh IJ; Springate BA; Bixby K; Murali M; Trikalinos TA J Gen Intern Med 2015[Mar]; 30 (3): 348-58 PMID25575908show ga BACKGROUND: In 2012, the United States Food and Drug Administration (FDA) issued a warning regarding potential adverse effects of HMG-CoA reductase inhibitors (statins) on cognition, based on the Adverse Events Reporting System and a review of the medical literature. We aimed to synthesize randomized clinical trial (RCTs) evidence on the association between statin therapy and cognitive outcomes. METHODS: We searched MEDLINE, EMBASE, and Cochrane CENTRAL through December 2012, and reviewed published systematic reviews of statin treatment. We sought RCTs that compared statin treatment versus placebo or standard care, and reported at least one cognitive outcome (frequency of adverse cognitive events or measurements using standard neuropsychological cognitive test scores). Studies reporting sufficient information to calculate effect sizes were included in meta-analyses. Standardized and unstandardized mean differences were calculated for continuous outcomes for global cognition and for pre-specified cognitive domains. The main outcome was change in cognition measured by neuropsychological tests; an outcome of secondary interest was the frequency of adverse cognitive events observed during follow-up. RESULTS: We identified 25 RCTs (all placebo-controlled) reporting cognitive outcomes in 46,836 subjects, of which 23 RCTs reported cognitive test results in 29,012 participants. Adverse cognitive outcomes attributable to statins were rarely reported in trials involving cognitively normal or impaired subjects. Furthermore, meta-analysis of cognitive test data (14 studies; 27,643 participants) failed to show significant adverse effects of statins on all tests of cognition in either cognitively normal subjects (standardized mean difference 0.01, 95 % confidence interval, CI, ?0.01 to 0.03, p?=?0.42) or Alzheimer?s disease subjects (standardized mean difference ?0.05, 95 % CI ?0.19 to 0.10, p?=?0.38). CONCLUSIONS: Statin therapy was not associated with cognitive impairment in RCTs. These results raise questions regarding the continued merit of the FDA warning about potential adverse effects of statins on cognition. Electronic supplementary material: The online version of this article (doi:10.1007/s11606-014-3115-3) contains supplementary material, which is available to authorized users. äDo Statins Impair Cognition? A Systematic Review and Meta-Analysis of (epmc).pdf DeepDyve Pubget Overpricing