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10.1016/j.celrep.2015.01.066 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.01.066 C4351187!4351187!25732823     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2015 ; 10 (8): 1324-34 Nephropedia Template TP {{tp|p=25732823|t=2015. DBC1 Functions as a Tumor Suppressor by Regulating p53 Stability |pdf=|usr=}}{{25732823}} gab.com Text DBC1 Functions as a Tumor Suppressor by Regulating p53 Stability JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25732823 #FOAvip DBC1 (deleted in breast cancer 1), also known as CCAR2 or KIAA1967 is an important negative regulator of SIRT1 and cellular stress response. Although the Dbc1 gene localizes at a region that is homozygously deleted in breast cancer, its role in tumorigenesis remains unclear. It has been suggested to be either a tumor suppressor or an oncogene. Therefore, the function of DBC1 in cancer needs to be further explored. Here we report that Dbc1 knockout mice are tumor prone, supporting that DBC1 functions as a tumor suppressor in vivo. Our data suggest that the increased tumor incidence in Dbc1 knockout mice is independent of Sirt1. Instead, we found that DBC1 loss results in less p53 protein in vitro and in vivo. DBC1 directly binds p53 and stabilizes it through competition with MDM2. These studies reveal that DBC1 plays an important role in tumor suppression through p53 regulation. Twit Text FOAVip DBC1 Functions as a Tumor Suppressor by Regulating p53 Stability ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25732823 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25732823 #FOAvip English Wikipedia <ref>{{Cite pmid|25732823}}</ref> DBC1 Functions as a Tumor Suppressor by Regulating p53 Stability #MMPMID25732823 Qin B; Minter-Dykhouse K; Yu J; Zhang J; Liu T; Zhang H; Lee SB; Kim JJ; Wang L; Lou Z Cell Rep 2015[Mar]; 10 (8): 1324-34 PMID25732823show ga DBC1 (deleted in breast cancer 1), also known as CCAR2 or KIAA1967 is an important negative regulator of SIRT1 and cellular stress response. Although the Dbc1 gene localizes at a region that is homozygously deleted in breast cancer, its role in tumorigenesis remains unclear. It has been suggested to be either a tumor suppressor or an oncogene. Therefore, the function of DBC1 in cancer needs to be further explored. Here we report that Dbc1 knockout mice are tumor prone, supporting that DBC1 functions as a tumor suppressor in vivo. Our data suggest that the increased tumor incidence in Dbc1 knockout mice is independent of Sirt1. Instead, we found that DBC1 loss results in less p53 protein in vitro and in vivo. DBC1 directly binds p53 and stabilizes it through competition with MDM2. These studies reveal that DBC1 plays an important role in tumor suppression through p53 regulation. äDBC1 Functions as a Tumor Suppressor by Regulating p53 Stability (epmc).pdf DeepDyve Pubget Overpricing