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10.1126/scitranslmed.3008411 http://scihub22266oqcxt.onion/10.1126/scitranslmed.3008411 C4350665!4350665!25520397     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Transl+Med 2014 ; 6 (267): 267ra176 Nephropedia Template TP {{tp|p=25520397|t=2014. A Wnt-TGF?2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice |pdf=|usr=}}{{25520397}} gab.com Text A Wnt-TGF 2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice JO: Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=25520397 #FOAvip We have previously observed that Wnt signaling activates a fibrogenic program in adult muscle stem cells, called satellite cells, during aging. We genetically labeled satellite cells in a mouse model of Duchenne muscular dystrophy to follow their fate during the progression of the disease. We observed that a fraction of satellite cells had a reduced myogenic potential and showed enhanced expression of profibrotic genes compared to age-matched controls. By combining in vitro and in vivo results, we found that expression of transforming growth factor??2 (TGF?2) was induced in response to elevated canonical Wnt signaling in dystrophic muscles and that the resulting increase in TGFb activity affected the behavior of satellite cells in an autocrine or paracrine fashion. Indeed, pharmacological inhibition of the TGFb pathway in vivo reduced the fibrogenic characteristics of satellite cells. These studies shed new light on the cellular and molecular mechanisms responsible for stem cell dysfunction in dystrophic muscle and may contribute to the development of more effective and specific therapeutic approaches for the prevention of muscle fibrosis. Twit Text FOAVip A Wnt-TGF 2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice ????Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=25520397 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25520397 #FOAvip English Wikipedia <ref>{{Cite pmid|25520397}}</ref> A Wnt-TGF?2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice #MMPMID25520397 Biressi S; Miyabara EH; Gopinath SD; Carlig PMM; Rando TA Sci Transl Med 2014[Dec]; 6 (267): 267ra176 PMID25520397show ga We have previously observed that Wnt signaling activates a fibrogenic program in adult muscle stem cells, called satellite cells, during aging. We genetically labeled satellite cells in a mouse model of Duchenne muscular dystrophy to follow their fate during the progression of the disease. We observed that a fraction of satellite cells had a reduced myogenic potential and showed enhanced expression of profibrotic genes compared to age-matched controls. By combining in vitro and in vivo results, we found that expression of transforming growth factor??2 (TGF?2) was induced in response to elevated canonical Wnt signaling in dystrophic muscles and that the resulting increase in TGFb activity affected the behavior of satellite cells in an autocrine or paracrine fashion. Indeed, pharmacological inhibition of the TGFb pathway in vivo reduced the fibrogenic characteristics of satellite cells. These studies shed new light on the cellular and molecular mechanisms responsible for stem cell dysfunction in dystrophic muscle and may contribute to the development of more effective and specific therapeutic approaches for the prevention of muscle fibrosis. äA Wnt-TGF?2 axis induces a fibrogenic program in muscle stem cells fro(epmc).pdf DeepDyve Pubget Overpricing